The CRISPR (clustered regularly interspaced short palindromic repeat)-Cas system is an
adaptive immune system of bacteria that has furnished several RNA-guided DNA …

This protocol describes a method to obtain spatially resolved proteomic maps of specific
compartments within living mammalian cells. An engineered peroxidase, APEX2, is genetically …

Many members of the protein kinase family have emerged as key targets for pharmacological
intervention, most notably in cancer. However, the high sequence and structural homology …

Purpose: Approximately 4.8 million stroke survivors are living in the community with some
level of disability requiring the assistance of family caregivers. Stroke family caregivers are …

Pregnant women who had a previous cesarean birth must choose whether to have a repeat
cesarean or to attempt a vaginal birth. Many of these women are candidates for a trial of …

Objective To evaluate the relationship between epigenetic patterns in sperm and fecundity.
Design Prospective study. Setting Academic andrology and in vitro fertilization laboratory. …

Introduction: Assessment of dialysis‐related symptoms is not currently a requirement for
hemodialysis (HD) providers in the United States. The purpose of this study was to describe …

Background Women's access to vaginal birth after cesarean (VBAC) in the United States
has declined steadily since the mid-1990s, with a current rate of 8.2%. In the State of Florida, …

Purpose: Stroke caregivers have been identified as a group at high risk for poor outcomes
as a result of the suddenness of stroke and a potentially high level of care needed due to …

The 518 protein kinases encoded in the human genome are exquisitely regulated and their
aberrant function(s) are often associated with human disease. Thus, in order to advance …