User profiles for K. J. Siddle
 | Katherine SiddlePostdoctoral fellow, Harvard University Verified email at broadinstitute.org Cited by 4178 |
[PDF][PDF] Benchmarking metagenomics tools for taxonomic classification
Metagenomic sequencing is revolutionizing the detection and characterization of microbial
species, and a wide variety of software tools are available to perform taxonomic classification …
species, and a wide variety of software tools are available to perform taxonomic classification …
[HTML][HTML] COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets
COVID-19, which is caused by SARS-CoV-2, can result in acute respiratory distress syndrome
and multiple organ failure 1 , 2 , 3 – 4 , but little is known about its pathophysiology. Here …
and multiple organ failure 1 , 2 , 3 – 4 , but little is known about its pathophysiology. Here …
[HTML][HTML] Multiplexed CRISPR-based microfluidic platform for clinical testing of respiratory viruses and identification of SARS-CoV-2 variants
The coronavirus disease 2019 (COVID-19) pandemic has demonstrated a clear need for
high-throughput, multiplexed and sensitive assays for detecting severe acute respiratory …
high-throughput, multiplexed and sensitive assays for detecting severe acute respiratory …
Phylogenetic analysis of SARS-CoV-2 in Boston highlights the impact of superspreading events
INTRODUCTION We used genomic epidemiology to investigate the introduction and spread
of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the Boston area …
of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the Boston area …
[PDF][PDF] Comparative transmissibility of SARS-CoV-2 variants delta and alpha in New England, USA
…, N Matluk, N Renzette, SE Turbett, KJ Siddle… - Cell Reports …, 2022 - cell.com
The SARS-CoV-2 Delta variant rose to dominance in mid-2021, likely propelled by an
estimated 40%–80% increased transmissibility over Alpha. To investigate if this ostensible …
estimated 40%–80% increased transmissibility over Alpha. To investigate if this ostensible …
Viral lineages in the 2022 RSV surge in the United States
RSV Surge and Viral Lineages, 2022 A surge in RSV infections occurred across the United
States in late 2022. In this report, multiple RSV lineages are identified as contributing to the …
States in late 2022. In this report, multiple RSV lineages are identified as contributing to the …
[HTML][HTML] Deployable CRISPR-Cas13a diagnostic tools to detect and report Ebola and Lassa virus cases in real-time
Recent outbreaks of viral hemorrhagic fevers (VHFs), including Ebola virus disease (EVD)
and Lassa fever (LF), highlight the urgent need for sensitive, deployable tests to diagnose …
and Lassa fever (LF), highlight the urgent need for sensitive, deployable tests to diagnose …
[HTML][HTML] Genomic analysis of Lassa virus during an increase in cases in Nigeria in 2018
During 2018, an unusual increase in Lassa fever cases occurred in Nigeria, raising concern
among national and international public health agencies. We analyzed 220 Lassa virus …
among national and international public health agencies. We analyzed 220 Lassa virus …
The Red Queen's long race: human adaptation to pathogen pressure
KJ Siddle, L Quintana-Murci - Current Opinion in Genetics & Development, 2014 - Elsevier
Pathogens, and the infectious diseases they cause, have been paramount among the threats
encountered by humans in their expansions throughout the globe. Numerous studies have …
encountered by humans in their expansions throughout the globe. Numerous studies have …
[HTML][HTML] The impact of agricultural emergence on the genetic history of African rainforest hunter-gatherers and agriculturalists
The emergence of agriculture in West-Central Africa approximately 5,000 years ago,
profoundly modified the cultural landscape and mode of subsistence of most sub-Saharan …
profoundly modified the cultural landscape and mode of subsistence of most sub-Saharan …