purpose. Intravitreal injection of brain-derived neurotrophic factor (BDNF), ciliary neurotrophic
factor (CNTF), or basic fibroblast growth factor (FGF2) promotes survival of photoreceptors …

technology, bioengineering, and machine learning, we can explore the ability of brain organoids
to compute, and store given information (input), execute a task (output), and study how …

The retinal degenerative diseases, which together constitute a leading cause of hereditary
blindness worldwide, are largely untreatable. Development of reliable methods to culture …

The microRNA-183/96/182 cluster is highly expressed in the retina and other sensory
organs. To uncover its in vivo functions in the retina, we generated a knockout mouse model, …

Age-related macular degeneration (AMD) is associated with dysfunction and death of retinal
pigment epithelial (RPE) cells. Cell-based approaches using RPE-like cells derived from …

X-linked juvenile retinoschisis (XLRS), linked to mutations in the RS1 gene, is a degenerative
retinopathy with a retinal splitting phenotype. We generated human induced pluripotent …

The advent of stem cell-derived retinal organoids has brought forth unprecedented opportunities
for developmental and physiological studies, while presenting new therapeutic promise …

Retinal degenerative disease involving photoreceptor (PR) cell loss results in permanent
vision loss and often blindness. Generation of induced pluripotent stem cell (iPSC)-derived …

Human pluripotent stem cells (PSCs) represent a powerful tool to investigate human eye
development and disease. When grown in 3D, they can self-assemble into laminar organized …

Epithelial-mesenchymal transition (EMT), which is well known for its role in embryonic
development, malignant transformation, and tumor progression, has also been implicated in a …