The identification and characterization of regulatory T (T Reg ) cells that can control immune
responsiveness to alloantigens have opened up exciting opportunities for new therapies in …

Immune regulation is fundamental to any immune response to ensure that it is appropriate
for the perceived threat to the host. Following cell and organ transplantation, it is essential to …

Rejection is the major barrier to successful transplantation. The immune response to an
allograft is an ongoing dialogue between the innate and adaptive immune system that if left …

Specific and selective immunological unresponsiveness to donor alloantigens can be induced
in vivo. We have shown previously that CD25+ CD4+ T cells from mice exhibiting long-…

We present evidence that donor-reactive CD4+ T cells present in mice tolerant to donor
alloantigens are phenotypically and functionally heterogeneous. CD4+ T cells contained within …

Identifying transplant recipients in whom immunological tolerance is established or is developing
would allow an individually tailored approach to their posttransplantation management. …

Background Use of cell-based medicinal products (CBMPs) represents a state-of-the-art
approach for reducing general immunosuppression in organ transplantation. We tested multiple …

Mesenchymal stromal/stem cells (MSCs) possess immunomodulatory and reparative
properties. Through specific interactions with immune cells that participate in both innate and …

Background Donor-specific antibodies create an immunologic barrier to transplantation.
Current therapies to modify donor-specific antibodies are limited and ineffective in the most …

The significance of cytokine production by CD4 + regulatory T (T reg) cells after antigen
exposure in vivo and its impact on their regulatory activity remains unclear. Pretreatment with …