Polycomb repressive complexes (PRCs) 1 and 2 are essential chromatin regulators of cell
identity. PRC1, a dominant executer of Polycomb-mediated control, functions as multiple sub-…

Merkel cells are innervated mechanosensory cells responsible for light-touch sensations. In
murine dorsal skin, Merkel cells are located in touch domes and found in the epidermis …

For neural systems to function effectively, the numbers of each cell type must be proportioned
properly during development. We found that conditional knockout of the mouse homeobox …

Background Owing to gonadotoxic cancer treatments, young adult female survivors often
report uncertainty about their fertility, reproductive potential, and family-building options after …

Background: Cystic fibrosis (CF) is a life-limiting genetic disease that causes chronic lung
infections. We developed an internet-based decision aid (DA) to help patients with CF make …

Background Clinicians often disregard potentially beneficial clinical decision support (CDS).
Objective In this study, we sought to explore the psychological and behavioral barriers to …

Background: An important aspect of patient-centered care involves ensuring that patient-directed
resources are usable, understandable, and responsive to patients’ needs. A user-…

Background Overprescribing of antibiotics for acute respiratory infections (ARIs) remains a
major issue in outpatient settings. Use of clinical prediction rules (CPRs) can reduce …

Polycomb repressive complexes (PRC) are essential chromatin regulators that control
tissue development and stem cells. While studies have revealed the functions of Polycomb …

Efficient function of neural systems requires the production of specific cell types in the correct
proportions. Here we report that reduction of the earliest born neurons of the cerebellum, …