Targeted protein degradation (TPD) by PROTAC (proteolysis-targeting chimera) and molecular
glue small molecules is an emerging therapeutic strategy. To expand the roster of E3 …

Producing novel enzymes that are catalytically active in vitro and biologically functional in
vivo is a key goal of synthetic biology. Here we describe Syn-F4, the first de novo protein that …

The human antiviral protein MxB is a restriction factor that fights HIV infection. Previous
experiments have demonstrated that MxB targets the HIV capsid, a protein shell that protects the …

The HIV-1 capsid is an ordered protein shell that houses the viral genome during early
infection. Its expansive surface consists of an ordered and interfacing array of capsid protein …

Recent advances in protein design rely on rational and computational approaches to create
novel sequences that fold and function. In contrast, natural systems selected functional …

Two-dimensional π-systems are of current interest in the design of functional organic
molecules, exhibiting unique behavior for applications in organic electronics, single-molecule …

An important goal of synthetic biology is to create novel proteins that provide life-sustaining
functions in living organisms. Recent attempts to produce novel proteins have focused …

The first X-ray structures of two anomeric N,N-dialkoxyamides (2 and 3) have been obtained,
which confirm that they are highly pyramidalized at nitrogen and have long N–CO bonds, a …

N,N-Dialkoxyamides 1c, a virtually unstudied member of the new class of anomeric amides,
amides bearing two electronegative atoms at nitrogen, have been synthesised in useful …

Background SAMHD1 mediates resistance to anti-cancer nucleoside analogues, including
cytarabine, decitabine, and nelarabine that are commonly used for the treatment of leukaemia…