Clustering is an unsupervised learning method, which groups data points based on similarity,
and is used to reveal the underlying structure of data. This computational approach is …

Reactivation of a silent transcriptional program is a critical step in successful axon
regeneration following injury. Yet how such a program is unlocked after injury remains largely …

3D patient tumor avatars (3D-PTAs) hold promise for next-generation precision medicine.
Here, we describe the benefits and challenges of 3D-PTA technologies and necessary future …

Collagen is an important extracellular matrix component that directs many fundamental
cellular processes including differentiation, proliferation and motility. The signalling networks …

Rationale: Mutations in the SCN5A gene, encoding the α subunit of the Nav1.5 channel, cause
a life-threatening form of cardiac arrhythmia, long QT syndrome type 3 (LQT3). Mexiletine…

The EGF receptor can bind seven different agonist ligands. Although each agonist appears
to stimulate the same suite of downstream signaling proteins, different agonists are capable …

… We are grateful to John Naegle for help with webpage styling, Brook Haley for help with
logo design, and Tom Ronan and Roman Sloutsky for critical reading and manuscript …

… Naegle … Citation: Naegle KM (2021) Ten simple rules for effective presentation slides.
PLoS Comput Biol 17(12): e1009554. https://doi.org/10.1371/journal.pcbi.1009554 …

Kinase inhibitors as targeted therapies have played an important role in improving cancer
outcomes. However, there are still considerable challenges, such as resistance, non-response…

Clustering is a powerful and commonly used technique that organizes and elucidates the
structure of biological data. Clustering data from gene expression, metabolomics and …