BACKGROUND By identifying pathogenic variants across hundreds of genes, expanded
carrier screening (ECS) enables prospective parents to assess the risk of transmitting an …

Purpose The percentage of a maternal cell-free DNA (cfDNA) sample that is fetal-derived (the
fetal fraction; FF) is a key driver of the sensitivity and specificity of noninvasive prenatal …

The dynamics of a protein along a well-defined coordinate can be formally projected onto
the form of an overdamped Lagevin equation. Here, we present a comprehensive statistical-…

Two methods are developed to enhance the stability, efficiency, and robustness of reaction
path optimization using a chain of replicas. First, distances between replicas are kept equal …

The past two decades have brought many important advances in our understanding of the
hereditary susceptibility to cancer. Numerous studies have provided convincing evidence that …

We propose to quantify the trajectory entropy of a dynamic system as the information content
in excess of a free-diffusion reference model. The space–time trajectory is now the dynamic …

Clinical genomic tests increasingly use a next-generation sequencing (NGS) platform due
in part to the high fidelity of variant calls, yet rare errors are still possible. In germline DNA …

The evaluation of the Fisher information matrix for the probability density of trajectories
generated by the over-damped Langevin dynamics at equilibrium is presented. The framework …

The analytical expression for the trajectory entropy of the overdamped Langevin equation is
derived via two approaches. The first route goes through the Fokker–Planck equation that …

We analyzed a genetic polymorphism of Fcγ receptor IIIa (CD16) that is present on position
158 (Phe or Val) in the membrane-proximal, IgG-binding domain. With a polymerase chain …