User profiles for K. R. Maynard
Kristen MaynardInvestigator, Lieber Institute for Brain Development Verified email at libd.org Cited by 1511 |
Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex
We used the 10x Genomics Visium platform to define the spatial topography of gene expression
in the six-layered human dorsolateral prefrontal cortex. We identified extensive layer-…
in the six-layered human dorsolateral prefrontal cortex. We identified extensive layer-…
[HTML][HTML] Challenges and opportunities to computationally deconvolve heterogeneous tissue with varying cell sizes using single-cell RNA-sequencing datasets
Deconvolution of cell mixtures in “bulk” transcriptomic samples from homogenate human
tissue is important for understanding disease pathologies. However, several experimental and …
tissue is important for understanding disease pathologies. However, several experimental and …
[PDF][PDF] Single-nucleus transcriptome analysis reveals cell-type-specific molecular signatures across reward circuitry in the human brain
MN Tran, KR Maynard, A Spangler, LA Huuki… - Neuron, 2021 - cell.com
Single-cell gene expression technologies are powerful tools to study cell types in the human
brain, but efforts have largely focused on cortical brain regions. We therefore created a …
brain, but efforts have largely focused on cortical brain regions. We therefore created a …
Profiling gene expression in the human dentate gyrus granule cell layer reveals insights into schizophrenia and its genetic risk
Specific cell populations may have unique contributions to schizophrenia but may be missed
in studies of homogenate tissue. Here laser capture microdissection followed by RNA …
in studies of homogenate tissue. Here laser capture microdissection followed by RNA …
[HTML][HTML] spatialLIBD: an R/Bioconductor package to visualize spatially-resolved transcriptomics data
Background Spatially-resolved transcriptomics has now enabled the quantification of high-throughput
and transcriptome-wide gene expression in intact tissue while also retaining the …
and transcriptome-wide gene expression in intact tissue while also retaining the …
[HTML][HTML] Functional role of BDNF production from unique promoters in aggression and serotonin signaling
Brain-derived neurotrophic factor (BDNF) regulates diverse biological functions ranging from
neuronal survival and differentiation during development to synaptic plasticity and cognitive …
neuronal survival and differentiation during development to synaptic plasticity and cognitive …
New technologies for essential newborn care in under-resourced areas: what is needed and how to deliver it
KR Maynard, L Causey, K Kawaza… - Paediatrics and …, 2015 - Taylor & Francis
Globally, the largest contributors to neonatal mortality are preterm birth, intrapartum
complications and infection. Many of these deaths could be prevented by providing temperature …
complications and infection. Many of these deaths could be prevented by providing temperature …
Antidepressant-like effects of electroconvulsive seizures require adult neurogenesis in a neuroendocrine model of depression
Background Neurogenesis continues throughout life in the hippocampal dentate gyrus.
Chronic treatment with monoaminergic antidepressant drugs stimulates hippocampal …
Chronic treatment with monoaminergic antidepressant drugs stimulates hippocampal …
dotdotdot: an automated approach to quantify multiplex single molecule fluorescent in situ hybridization (smFISH) images in complex tissues
KR Maynard, M Tippani, Y Takahashi… - Nucleic acids …, 2020 - academic.oup.com
Multiplex single-molecule fluorescent in situ hybridization (smFISH) is a powerful method for
validating RNA sequencing and emerging spatial transcriptomic data, but quantification …
validating RNA sequencing and emerging spatial transcriptomic data, but quantification …
Bdnf mRNA splice variants differentially impact CA1 and CA3 dendrite complexity and spine morphology in the hippocampus
KR Maynard, JW Hobbs, M Sukumar… - Brain Structure and …, 2017 - Springer
Brain-derived neurotrophic factor (BDNF) is an activity-dependent neurotrophin critical for
neuronal plasticity in the hippocampus. BDNF is encoded by multiple transcripts with …
neuronal plasticity in the hippocampus. BDNF is encoded by multiple transcripts with …