Invasion-inhibitory antibodies elicited by immunization with Plasmodium vivax apical membrane antigen-1 expressed in Pichia pastoris yeast

EC Vicentin, KS Françoso, MV Rocha… - Infection and …, 2014 - Am Soc Microbiol
In a recent vaccine trial performed with African children, immunization with a recombinant
protein based on Plasmodium falciparum apical membrane antigen 1 (AMA-1) conferred a …

[HTML][HTML] A recombinant vaccine based on domain II of Plasmodium vivax Apical Membrane Antigen 1 induces high antibody titres in mice

F Gentil, DY Bargieri, JA Leite, KS Françoso… - Vaccine, 2010 - Elsevier
The Apical Membrane Antigen 1 (AMA-1) is considered a promising candidate for development
of a malaria vaccine against asexual stages of Plasmodium. We recently identified …

[HTML][HTML] Prime-boost vaccination with recombinant protein and adenovirus-vector expressing Plasmodium vivax circumsporozoite protein (CSP) partially protects …

…, LC Lima, K de Almeida Caramico, KS Françoso… - Scientific reports, 2018 - nature.com
Vaccine development against Plasmodium vivax malaria lags behind that for Plasmodium
falciparum. To narrow this gap, we administered recombinant antigens based on P. vivax …

[HTML][HTML] Therapeutic treatment with scFv–PLGA nanoparticles decreases pulmonary fungal load in a murine model of paracoccidioidomycosis

GP Jannuzzi, N de Araújo Souza, KS Françoso… - Microbes and …, 2018 - Elsevier
Paracoccidioidomycosis (PCM) is a systemic mycosis with lymphatic dissemination that is
caused by Paracoccidioides species. Treatment of PCM consists of chemotherapeutics such …

[HTML][HTML] Vaccine Containing the Three Allelic Variants of the Plasmodium vivax Circumsporozoite Antigen Induces Protection in Mice after Challenge with a …

AM Gimenez, LC Lima, KS Francoso… - Frontiers in …, 2017 - frontiersin.org
Plasmodium vivax is the most common species that cause malaria outside of the African
continent. The development of an efficacious vaccine would contribute greatly to control malaria…

[HTML][HTML] A recombinant multi-antigen vaccine formulation containing Babesia bovis merozoite surface antigens MSA-2a1, MSA-2b and MSA-2c elicits invasion …

AM Gimenez, KS Françoso, J Ersching, MY Icimoto… - Parasites & vectors, 2016 - Springer
Background Babesia bovis is a tick-transmitted protozoan hemoparasite and the causative
agent of bovine babesiosis, a potential risk to more than 500 million cattle worldwide. The …

Generation, characterization and immunogenicity of a novel chimeric recombinant protein based on Plasmodium vivax AMA-1 and MSP119

MV Rocha, KS Françoso, LC Lima, TM Camargo… - Vaccine, 2017 - Elsevier
Plasmodium vivax is the most widely distributed malaria species and the most prevalent
species of malaria in America and Asia. Vaccine development against P. vivax is considered a …

[HTML][HTML] Febrile temperatures increase in vitro antibody affinity for malarial and dengue antigens

RC Stan, KS Francoso, RPS Alves… - PLoS Neglected …, 2019 - journals.plos.org
Fever is a regulated increase of the body temperature resulting from both infectious and non-infectious
causes. Fever is known to play a role in modulating immune responses to …

Poly I:C elicits broader and stronger humoral and cellular responses to a Plasmodium vivax circumsporozoite protein malaria vaccine than Alhydrogel in mice

TBL Costa-Gouvea, KS Françoso, RF Marques… - Frontiers in …, 2024 - frontiersin.org
Malaria remains a global health challenge, necessitating the development of effective
vaccines. The RTS,S vaccination prevents Plasmodium falciparum (Pf) malaria but is ineffective …

[HTML][HTML] A Multistage Formulation Based on Full-Length CSP and AMA-1 Ectodomain of Plasmodium vivax Induces High Antibody Titers and T-cells and Partially Protects Mice …

LC Lima, RF Marques, AM Gimenez, KS Françoso… - Microorganisms, 2020 - mdpi.com
Infections with Plasmodium vivax are predominant in the Americas, representing 75% of
malaria cases. Previously perceived as benign, malaria vivax is, in fact, a highly debilitating and …