Epigenetic clocks comprise a set of CpG sites whose DNA methylation levels measure
subject age. These clocks are acknowledged as a highly accurate molecular correlate of …

Epigenome-wide association studies (EWAS) hold promise for the detection of new regulatory
mechanisms that may be susceptible to modification by environmental and lifestyle factors …

Lung carcinomas and pulmonary fibrosis (asbestosis) occur in asbestos workers. Understanding
the pathogenesis of these diseases is complicated because of potential confounding …

Background There has been a long-standing need in biomedical research for a method that
quantifies the normally mixed composition of leukocytes beyond what is possible by simple …

Epigenetic control of gene transcription is critical for normal human development and cellular
differentiation. While alterations of epigenetic marks such as DNA methylation have been …

With the release of the landmark report Toxicity Testing in the 21st Century: A Vision and a
Strategy, the US National Academy of Sciences, in 2007, precipitated a major change in the …

Polymorphisms in several DNA repair genes have recently been identified, but little is known
about their phenotypic significance. To determine whether variation in DNA repair genes is …

Background Sexual contact may be the means by which head and neck cancer patients are
exposed to human papillomavirus (HPV). Methods We undertook a pooled analysis of four …

Human papillomaviruses (HPV) are associated with nearly all cervical cancers, 20% to 30%
of head and neck cancers (HNC), and other cancers. Because HNCs also arise in HPV-…

Recent work has begun to explore the instrumental role that small noncoding RNA species,
particularly microRNAs (miRNA), have both in classifying human tumors and in directing …