Cell geometric constraints induce modular gene-expression patterns via redistribution of HDAC3 regulated by actomyosin contractility
Physical forces in the form of substrate rigidity or geometrical constraints have been shown
to alter gene expression profile and differentiation programs. However, the underlying …
to alter gene expression profile and differentiation programs. However, the underlying …
[PDF][PDF] Mechanical activation of cells induces chromatin remodeling preceding MKL nuclear transport
For cells to adapt to different tissues and changes in tissue mechanics, they must be able to
respond to mechanical cues by changing their gene expression patterns. Biochemical …
respond to mechanical cues by changing their gene expression patterns. Biochemical …
[PDF][PDF] Epithelial viscoelasticity is regulated by mechanosensitive E-cadherin turnover
Studying how epithelia respond to mechanical stresses is key to understanding tissue
shape changes during morphogenesis. Here, we study the viscoelastic properties of the …
shape changes during morphogenesis. Here, we study the viscoelastic properties of the …
Chromosome intermingling—the physical basis of chromosome organization in differentiated cells
S Maharana, KV Iyer, N Jain, M Nagarajan… - Nucleic acids …, 2016 - academic.oup.com
Chromosome territories (CTs) in higher eukaryotes occupy tissue-specific non-random three-dimensional
positions in the interphase nucleus. To understand the mechanisms …
positions in the interphase nucleus. To understand the mechanisms …
Molecular highway patrol for ribosome collisions
During translation, messenger RNAs (mRNAs) are decoded by ribosomes which can stall
for various reasons. These include chemical damage, codon composition, starvation, or …
for various reasons. These include chemical damage, codon composition, starvation, or …
Self-organized patterning of cell morphology via mechanosensitive feedback
Tissue organization is often characterized by specific patterns of cell morphology. How such
patterns emerge in developing tissues is a fundamental open question. Here, we investigate …
patterns emerge in developing tissues is a fundamental open question. Here, we investigate …
A high-frequency AC-link single-stage asymmetrical multilevel converter for grid integration of renewable energy systems
KV Iyer, R Baranwal, N Mohan - IEEE Transactions on Power …, 2016 - ieeexplore.ieee.org
… 2, the ac–ac converter Module I should have IGBTs rated at 6.5 kV, whereas Module II
should have IGBTs rated at 3.5 kV and Module III at 1.7 kV. Each module consists of four bidirec…
should have IGBTs rated at 3.5 kV and Module III at 1.7 kV. Each module consists of four bidirec…
A reduced switch count single-stage three-phase bidirectional rectifier with high-frequency isolation
Dual active bridge (DAB) based converters offer the benefit of smaller volume due to high-frequency
isolation and controllability of active power flow, making them attractive for various …
isolation and controllability of active power flow, making them attractive for various …
Anti-tumorigenic effects of resveratrol in lung cancer cells through modulation of c-FLIP
C Wright, KV Iyer, JS Yakisich… - Current cancer drug …, 2017 - ingentaconnect.com
Background: Resveratrol has been shown to have antioxidant and anti-proliferative properties
in multiple cancer types. Here we demonstrate that H460 lung cancer cells are more …
in multiple cancer types. Here we demonstrate that H460 lung cancer cells are more …
[HTML][HTML] Clinicoepidemiological features and mortality analysis of deceased patients with COVID-19 in a tertiary care center
Results A total of 654 adult patients were admitted in the ICU during the study period and
ICU mortality was 37.7%(247/654). Among the adult deceased, 65.9% were males with a …
ICU mortality was 37.7%(247/654). Among the adult deceased, 65.9% were males with a …