Rationale: The contributions of diverse cell populations in the human lung to pulmonary
fibrosis pathogenesis are poorly understood. Single-cell RNA sequencing can reveal changes …

Little is known about the relative importance of monocyte and tissue-resident macrophages
in the development of lung fibrosis. We show that specific genetic deletion of monocyte-…

Aging is among the most important risk factors for morbidity and mortality. To contribute toward
a molecular understanding of aging, we analyzed age-resolved transcriptomic data from …

Alveolar macrophages orchestrate the response to viral infections. Age-related changes in
these cells may underlie the differential severity of pneumonia in older patients. We …

Tregs require Foxp3 expression and induction of a specific DNA hypomethylation signature
during development, after which Tregs persist as a self-renewing population that regulates …

Background Epithelial barrier dysfunction is a central feature in the pathogenesis of allergic
disease. Epithelial‐to‐mesenchymal transition ( EMT ) has been proposed as one …

Primary graft dysfunction is the predominant driver of mortality and graft loss after lung
transplantation. Recruitment of neutrophils as a result of ischemia-reperfusion injury is thought to …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected more than
180 million people since the onset of the pandemic. Despite similar viral load and infectivity …

… We then investigated differences between groups with k-means clustering of DEGs. Based on
… We applied this algorithm to each k-means cluster and obtained a pattern of promoter CpG …

Rationale: The identification of informative elements of the host response to infection may
improve the diagnosis and management of bacterial pneumonia. Objectives: To determine …