User profiles for K. Billiar

Kristen Billiar

Professor and Department Head, Biomedical Engineering, Worcester Polytechnic Institute
Verified email at wpi.edu
Cited by 5335

Biaxial mechanical properties of the natural and glutaraldehyde treated aortic valve cusp—part I: experimental results

KL Billiar, MS Sacks - J. Biomech. Eng., 2000 - asmedigitalcollection.asme.org
To date, there are no constitutive models for either the natural or bioprosthetic aortic valve (AV),
in part due to experimental complications related to the AV’s small size and …

Biaxial mechanical properties of the native and glutaraldehyde-treated aortic valve cusp: part II—a structural constitutive model

KL Billiar, MS Sacks - J. Biomech. Eng., 2000 - asmedigitalcollection.asme.org
… where T ij k are the estimated tension values and Tij k are the measured tensions evaluated
for the kth data point. In the current study k ranges over the data sets from protocols 2 …

Mechanical regulation of apoptosis in the cardiovascular system

ZE Goldblatt, HA Cirka, KL Billiar - Annals of biomedical engineering, 2021 - Springer
Apoptosis is a highly conserved physiological process of programmed cell death which is
critical for proper organism development, tissue maintenance, and overall organism …

Problem-based learning in biomechanics: Advantages, challenges, and implementation strategies

AM Clyne, KL Billiar - Journal of biomechanical …, 2016 - asmedigitalcollection.asme.org
… PBL also emphasizes critical skills needed by biomechanical engineers in industry,
specifically ABET a–k outcomes that are ranked most important by employers [11]. These include …

A method to quantify the fiber kinematics of planar tissues under biaxial stretch

KL Billiar, MS Sacks - Journal of biomechanics, 1997 - Elsevier
We have developed a method for measuring fiber kinematics in two-dimensional soft
collagenous tissues. The technique combines small-angle light scattering (SALS) and biaxial …

Regulating tension in three-dimensional culture environments

MH Kural, KL Billiar - Experimental cell research, 2013 - Elsevier
… VIC-populated fibrin gels were cultured for 5 days anchored by flexible but relatively stiff
boundaries (k=1.1 nN/nm) with either 0 or 5 ng/mL TGF-β1 and either 0 or 5 µM Blebbistatin. (a) …

Evaluation of the porcine intestinal collagen layer as a biomaterial

GA Abraham, J Murray, K Billiar… - Journal of Biomedical …, 2000 - Wiley Online Library
The submucosal layer of the small intestine has been investigated as a source of collagenous
tissue with the potential to be used as a biomaterial because of its inherent strength and …

[HTML][HTML] Combining Dynamic Stretch and Tunable Stiffness to Probe Cell Mechanobiology In Vitro

…, LN Sierad, AK Capulli, LE Firstenberg, KL Billiar - PloS one, 2011 - journals.plos.org
Cells have the ability to actively sense their mechanical environment and respond to both
substrate stiffness and stretch by altering their adhesion, proliferation, locomotion, morphology, …

Investigating the role of substrate stiffness in the persistence of valvular interstitial cell activation

AMT Quinlan, KL Billiar - Journal of biomedical materials …, 2012 - Wiley Online Library
… For example, for area/cell, 150 Pa is only significantly different from 76.8 and 154 kPa groups
(designated by letters j and k). Data from the first experimental run are shown in the graphs…

[PDF][PDF] Nonlinear strain stiffening is not sufficient to explain how far cells can feel on fibrous protein gels

…, HA Cirka, M Aghvami, EA Sander, Q Wen, KL Billiar - Biophysical journal, 2013 - cell.com
… acid-extracted (telopeptide-rich) collagen was utilized as a coating rather than acidic
pepsin-extracted collagen, which is less likely to form fibrous networks (AM Quinlan and KL Billiar, …