The delivery of drugs to a target site frequently involves crossing biological barriers. The
degree and nature of the impediment to flux, as well as the potential approaches to overcoming …

Mutations in NOTCH1 are frequently detected in patients with T-cell acute lymphoblastic
leukemia (T-ALL) and in mouse T-ALL models. Treatment of mouse or human T-ALL cell lines in …

The National Cancer Institute (NCI) Genomic Data Commons (GDC) contains more than 2.9
petabytes of genomic and associated clinical data from more than 60 NCI-funded and other …

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy largely caused by
aberrant activation of the TAL1/SCL, LMO1/2, and NOTCH1 oncogenes. Approximately 30% …

… thermophoresis (MST), allowing determination of K d values. PS modification improved
the binding affinity of aptamer to TTX by a factor of 2, from a K d of 29.5 ± 2.1 μM for the …

Abstract Interpretation of genetic variation is needed for deciphering genotype-phenotype
associations, mechanisms of inherited disease, and cancer driver mutations. Millions of single …

Castor is a zinc finger transcription factor that controls cell fate within neuroblast cell lineages
in Drosophila melanogaster. Here, we describe the cloning and characterization of a …

Dockstore ( https://dockstore.org/ ) is an open source platform for publishing, sharing, and
finding bioinformatics tools and workflows. The platform has facilitated large-scale biomedical …

Astrocytic glutamate transporters are crucial for glutamate homeostasis in the brain, and
dysregulation of these transporters can contribute to the development of epilepsy. Glutamate …

Drug delivery directly across the tympanic membrane (TM) could eliminate systemic exposure
to antibiotics prescribed for otitis media, the most common reason for pediatricians to …