Atrial fibrillation (AF) is commonly associated with heart failure. A bidirectional relationship
exists between the two—AF exacerbates heart failure causing a significant increase in heart …

Cardiovascular disease is the main cause of death globally, accounting for over 17 million
deaths each year. As the incidence of cardiovascular disease rises markedly with age, the …

Central to controlling intracellular calcium concentration ([Ca 2+ ] i ) are a number of Ca 2+
transporters and channels with the L-type Ca 2+ channel, Na + –Ca 2+ exchanger and …

Background— In ventricular myocytes, the majority of structures that couple excitation to the
systolic rise of Ca 2+ are located at the transverse tubular (t-tubule) membrane. In the failing …

… Table 3 summarises the mean values for B max and K d , whilst the K d of the intracellular
buffers is not different, the maximal buffering capacity (B max ) is increased by 305% in atrial …

Transverse (t) tubules are surface membrane invaginations that are present in all mammalian
cardiac ventricular cells. The apposition of L-type Ca 2+ channels on t tubules with the …

Rationale: Transverse tubules (t-tubules) regulate cardiac excitation–contraction coupling
and exhibit interchamber and interspecies differences in expression. In cardiac disease, t-…

… The rate of non-NCX–mediated Ca 2+ extrusion (k slow ) was unchanged between CTL
and … Nevertheless, protein expression levels of sarcolemmal Na + /K + ATPase (NKA) were …

The incidence of heart failure (HF) increases with age. This study sought to determine whether
aging exacerbates structural and functional remodeling of the myocardium in HF. HF was …

Background CRISPR-Cas9 gene-editing technology has facilitated the generation of knockout
mice, providing an alternative to cumbersome and time-consuming traditional embryonic …