User profiles for K. Flisikowski

Krzysztof Flisikowski

Chair of Livestock Biotechnology, Technical University of Munich
Verified email at tum.de
Cited by 3152

Dissection of Genetic Factors Modulating Fetal Growth in Cattle Indicates a Substantial Role of the Non-SMC Condensin I Complex, Subunit G (NCAPG) Gene

…, A Takasuga, K Setoguchi, R Pfuhl, K Flisikowski… - Genetics, 2009 - academic.oup.com
… is k and otherwise 0, g k is the allelic effect of allele k, u i is the infinitesimal genetic effect
of individual i, and e ihk is the residual. Multiple testing of a total of 52 markers had to be …

[HTML][HTML] Efficient production of multi-modified pigs for xenotransplantation by 'combineering', gene stacking and gene editing

…, A Buermann, T Flisikowska, K Flisikowski… - Scientific reports, 2016 - nature.com
Xenotransplantation from pigs could alleviate the shortage of human tissues and organs for
transplantation. Means have been identified to overcome hyperacute rejection and acute …

Genome-wide association study identifies two major loci affecting calving ease and growth-related traits in cattle

H Pausch, K Flisikowski, S Jung, R Emmerling… - Genetics, 2011 - academic.oup.com
… The resulting test statistic is equal to (N − K − 1) times the squared correlation and χ 2
distributed, where N is the number of samples and K the number of axes with an eigenvalue that …

[HTML][HTML] Whole genome sequencing of a single Bos taurusanimal for single nucleotide polymorphism discovery

SH Eck, A Benet-Pagès, K Flisikowski, T Meitinger… - Genome biology, 2009 - Springer
… A comparison with the genotypes of the same animal, generated on a 50 k oligonucleotide
chip, revealed a detection rate of 74% and 30% for homozygous and heterozygous SNPs, …

[HTML][HTML] A collection of bacterial isolates from the pig intestine reveals functional and taxonomic diversity

…, L Ly, JMP Alves, M Reichlin, K Flisikowski… - Nature …, 2020 - nature.com
Our knowledge about the gut microbiota of pigs is still scarce, despite the importance of these
animals for biomedical research and agriculture. Here, we present a collection of cultured …

[HTML][HTML] Factors influencing the efficiency of generating genetically engineered pigs by nuclear transfer: multi-factorial analysis of a large data set

…, A Baehr, K Kraehe, K Burkhardt, K Flisikowski… - BMC …, 2013 - Springer
Background Somatic cell nuclear transfer (SCNT) using genetically engineered donor cells
is currently the most widely used strategy to generate tailored pig models for biomedical …

Viable pigs after simultaneous inactivation of porcine MHC class I and three xenoreactive antigen genes GGTA1, CMAH and B4GALNT2

…, A Fischer, B Klinger, W Liang, K Flisikowski… - …, 2020 - Wiley Online Library
Background Cell surface carbohydrate antigens play a major role in the rejection of porcine
xenografts. The most important for human recipients are α‐1,3 Gal (Galactose‐alpha‐1,3‐…

[HTML][HTML] Homozygous haplotype deficiency reveals deleterious mutations compromising reproductive and rearing success in cattle

…, H Schwarzenbacher, J Burgstaller, K Flisikowski… - BMC genomics, 2015 - Springer
… We imputed rs110793536 into a larger cohort of 10,363 adult Fleckvieh animals genotyped
with 54 K and 700 K SNP arrays using 145 sequenced Fleckvieh animals as reference …

[HTML][HTML] Rapid discovery of de novo deleterious mutations in cattle enhances the value of livestock as model species

…, C Klopp, D Esquerre, C Wurmser, K Flisikowski… - Scientific Reports, 2017 - nature.com
… characterized by a generalized shortening of long bones (k,l). BD has been reported in 4%
of crossbred calves from a Charolais bull (BD1, k), in 21% of purebred calves from a Holstein …

[HTML][HTML] Inactivation and inducible oncogenic mutation of p53 in gene targeted pigs

…, M Kurome, V Zakhartchenko, B Kessler, K Flisikowski… - 2012 - journals.plos.org
Mutation of the tumor suppressor p53 plays a major role in human carcinogenesis. Here we
describe gene-targeted porcine mesenchymal stem cells (MSCs) and live pigs carrying a …