User profiles for K. Frontzek

Karl Frontzek

University College London, Institute of Neurology
Verified email at ucl.ac.uk
Cited by 1394

Toward therapy of human prion diseases

…, AKK Lakkaraju, K Frontzek - Annual review of …, 2018 - annualreviews.org
Three decades after the discovery of prions as the cause of Creutzfeldt-Jakob disease and
other transmissible spongiform encephalopathies, we are still nowhere close to finding an …

Intracerebral endotheliitis and microbleeds are neuropathological features of COVID‐19

…, P Steiger, A Aguzzi, K Frontzek - Neuropathology and …, 2021 - Wiley Online Library
Coronavirus disease 19 (COVID‐19) is a rapidly evolving pandemic caused by the coronavirus
Sars‐CoV‐2. Clinically manifest central nervous system symptoms have been described …

Inflammatory olfactory neuropathy in two patients with COVID-19

…, M Witt, T Hummel, P Steiger, A Aguzzi, K Frontzek - The Lancet, 2020 - thelancet.com
We report two cases of olfactory neuropathy diagnosed at autopsy in patients with severe
acute respiratory syndrome coronavirus 2 (SARSCoV2) infection. One patient experienced …

Amyloid-β pathology and cerebral amyloid angiopathy are frequent in iatrogenic Creutzfeldt-Jakob disease after dural grafting

K Frontzek, MI Lutz, A Aguzzi, GG Kovacs… - Swiss medical …, 2016 - zora.uzh.ch
QUESTIONS UNDER STUDY: Alzheimer-type amyloid-β (Aβ) pathology was reported in
brains of individuals developing iatrogenic Creutzfeldt-Jakob disease (iCJD) after treatment …

Large and small cerebral vessel involvement in severe COVID-19: detailed clinical workup of a case series

…, S Winklhofer, LL Imbach, D Kirschenbaum, K Frontzek… - Stroke, 2020 - Am Heart Assoc
… Karl Frontzek Karl Frontzek … Dr Frontzek received an unrestricted research grant from
Ono Pharmaceuticals outside of the submitted work. The other authors report no conflicts. …

COVID-19 targets human adrenal glands

…, L Laks, LS Chen, K Frontzek… - The Lancet Diabetes & …, 2022 - thelancet.com
COVID-19 develops due to infection with SARS-CoV-2, which particularly in elderly with
certain comorbidities (eg, metabolic syndrome) 1 can cause severe pneumonia and acute …

The relationship between total and regional corpus callosum atrophy, cognitive impairment and fatigue in multiple sclerosis patients

Ö Yaldizli, IK Penner, K Frontzek… - Multiple Sclerosis …, 2014 - journals.sagepub.com
Objective: The objective of this paper is to investigate the relationship between total and
regional corpus callosum (CC) atrophy, neuropsychological test performance and fatigue in …

[HTML][HTML] CD36-mediated activation of endothelial cell apoptosis by an N-terminal recombinant fragment of thrombospondin-2 inhibits breast cancer growth and …

…, F Hussein, A Woeste, C Gründker, K Frontzek… - Breast cancer research …, 2011 - Springer
Thus far the clinical benefits seen in breast cancer patients treated with drugs targeting the
vascular endothelial growth factor (VEGF) pathway are only modest. Consequently, …

68Gallium-DOTATATE PET in meningioma: A reliable predictor of tumor growth rate?

M Sommerauer, JK Burkhardt, K Frontzek… - Neuro …, 2016 - academic.oup.com
Background DOTATATE-based radionuclides have added new options in the diagnosis and
treatment of meningiomas; however, a reliable predictor of tumor growth has still not been …

Identification of novel risk loci and causal insights for sporadic Creutzfeldt-Jakob disease: a genome-wide association study

…, MD Geschwind, A Golubjatnikov, K Frontzek… - The Lancet …, 2020 - thelancet.com
Background Human prion diseases are rare and usually rapidly fatal neurodegenerative
disorders, the most common being sporadic Creutzfeldt-Jakob disease (sCJD). Variants in the …