During mitosis, two centrosomes form spindle poles and direct the formation of bipolar mitotic
spindles, which is an essential event for accurate chromosome segregation into daughter …

Chromosome instability, which is equated to mitotic defects and consequential chromosome
segregation errors, provides a formidable basis for the acquisition of further malignant …

… and ability to re-duplicate centrosomes (K Fukasawa, unpublished data). From these
observations, it is clear that p53 is also involved in suppression of re-duplication of centrosomes. …

Anthrax lethal toxin, produced by the bacterium Bacillus anthracis, is the major cause of
death in animals infected with anthrax. One component of this toxin, lethal factor (LF), is …

… K+ ATPase. Tight coupling between Na+, K+ ATPase-mediated changes in intracellular ATP
and K,ATP channel activity has been demonstrated in the renal proximal tubule [K. Tsuchiya…

In animal cells, duplication of centrosomes and DNA is coordinated. Since CDK2/cyclin E
triggers initiation of both events, activation of CDK2/cyclin E is thought to link these two events. …

OBJECTIVE: The Karolinska sleepiness scale (KSS) is frequently used for evaluating
subjective sleepiness. The main aim of the present study was to investigate the validity and …

… Flow cytometry and the BrdU incorporation assay were performed as described [K. Fukasawa
et al., Oncogene 10, 1 (1995)]. Briefly, BrdU and 5'-fluoro-2'-deoxyuridine (10:1 ratio) were …

Anion conductive aromatic multiblock copolymers, poly(arylene ether)s containing quaternized
ammonio-substituted fluorene groups, were synthesized via block copolycondensation of …

Wee1 is a tyrosine kinase that phosphorylates and inactivates CDC2 and is involved in G 2
checkpoint signaling. Because p53 is a key regulator in the G 1 checkpoint, p53-deficient …