… Nevertheless, the formation of [ 3 H]KDS from l-[ 3 H]serine is competitively inhibited by d-serine
with an IC 50 of ∼0.3 mM, which is a value similar to the K m of l-serine for the SPT …

The transport and sorting of lipids from the sites of their synthesis to their appropriate
destinations are fundamental for membrane biogenesis. In the synthesis of sphingolipids in …

Synthesis and sorting of lipids are essential for membrane biogenesis; however, the
mechanisms underlying the transport of membrane lipids remain little understood. Ceramide is …

… of Takuji Okusaka as chairman; Masafumi Nakamura as the vice-chairman; Masahiro Yoshida,
Masayuki Kitano, Katsuhiko Uesaka, Yoshinori Ito, Junji Furuse, and Keiji Hanada as the …

We report the draft genome sequence of the model moss Physcomitrella patens and compare
its features with those of flowering plants, from which it is separated by more than 400 …

1. L-trans-Epoxysuccinyl-leucylamido(4-guanidino)butane (E-64) at a concentration of 0.5
mM had no effect on the serine proteinases plasma kallikrein and leucocyte elastase or the …

Hematopoietic stem cells (HSCs) supply all blood cells throughout life by making use of their
self-renewal and multilineage differentiation capabilities. A monoclonal antibody raised to …

The accurate identification of antitumor T cell receptors (TCRs) represents a major challenge
for the engineering of cell-based cancer immunotherapies. By mapping 55 neoantigen-…

Adoptive transfer of tumor-infiltrating lymphocytes (TILs) can mediate regression of metastatic
melanoma; however, TILs are a heterogeneous population, and there are no effective …

Plants have substantially higher gene duplication rates compared with most other eukaryotes.
These plant gene duplicates are mostly derived from whole genome and/or tandem …