User profiles for K. Hayer
Katharina E HayerBioinformatics Scientist III, DBHi, Children's Hospital of Philadelphia Verified email at EMAIL.CHOP.EDU Cited by 2327 |
Impaired death receptor signaling in leukemia causes antigen-independent resistance by inducing CAR T-cell dysfunction
Resistance to CART19 is a significant barrier to efficacy in the treatment of B-cell malignancies.
This work demonstrates that impaired death receptor signaling in tumor cells causes …
This work demonstrates that impaired death receptor signaling in tumor cells causes …
CircaDB: a database of mammalian circadian gene expression profiles
CircaDB ( http://circadb.org ) is a new database of circadian transcriptional profiles from time
course expression experiments from mice and humans. Each transcript’s expression was …
course expression experiments from mice and humans. Each transcript’s expression was …
Simulation-based comprehensive benchmarking of RNA-seq aligners
Alignment is the first step in most RNA-seq analysis pipelines, and the accuracy of
downstream analyses depends heavily on it. Unlike most steps in the pipeline, alignment is …
downstream analyses depends heavily on it. Unlike most steps in the pipeline, alignment is …
[HTML][HTML] DNA double-strand breaks induce H2Ax phosphorylation domains in a contact-dependent manner
… For Cut and Run-seq 500 k cells were processed as described 28,53 . Cells were washed
1× with cut and run wash buffer (20 mM HEPES, pH 7.5, 150 mM NaCl, 0.5 mM spermidine), …
1× with cut and run wash buffer (20 mM HEPES, pH 7.5, 150 mM NaCl, 0.5 mM spermidine), …
Effectiveness of advanced versus conventional wound dressings on healing of chronic wounds: systematic review and meta-analysis
K Heyer, M Augustin, K Protz, K Herberger, C Spehr… - Dermatology, 2013 - karger.com
Background: Wound dressings are essential in the treatment of chronic wounds and should
be selected on valid and recent evidence. Objective: Effectiveness of advanced compared to …
be selected on valid and recent evidence. Objective: Effectiveness of advanced compared to …
[HTML][HTML] IVT-seq reveals extreme bias in RNA sequencing
NF Lahens, IH Kavakli, R Zhang, K Hayer, MB Black… - Genome biology, 2014 - Springer
… To eliminate NotI and possible RNase in reaction mixture, the sample was subjected to
Proteinase K treatment. SDS and Proteinase K were added to the reaction mixture to a final …
Proteinase K treatment. SDS and Proteinase K were added to the reaction mixture to a final …
[HTML][HTML] Direct RNA sequencing reveals m6A modifications on adenovirus RNA are necessary for efficient splicing
Adenovirus is a nuclear replicating DNA virus reliant on host RNA processing machinery.
Processing and metabolism of cellular RNAs can be regulated by METTL3, which catalyzes …
Processing and metabolism of cellular RNAs can be regulated by METTL3, which catalyzes …
[HTML][HTML] Extreme resistance to weak-acid preservatives in the spoilage yeast Zygosaccharomyces bailii
…, G Nebe-von-Caron, M Novodvorska, K Hayer… - International journal of …, 2013 - Elsevier
Weak-acid preservatives, such as sorbic acid and acetic acid, are used in many low pH foods
to prevent spoilage by fungi. The spoilage yeast Zygosaccharomyces bailii is notorious for …
to prevent spoilage by fungi. The spoilage yeast Zygosaccharomyces bailii is notorious for …
[HTML][HTML] STAT3–BDNF–TrkB signalling promotes alveolar epithelial regeneration after lung injury
… b, K-means analysis was used to subdivide AT2 cells into groups based on their individual
gene expression. Only groups 1, 2, and 3 are indicated, as the others have not been fully …
gene expression. Only groups 1, 2, and 3 are indicated, as the others have not been fully …
Benchmark analysis of algorithms for determining and quantifying full-length mRNA splice forms from RNA-seq data
Motivation: Because of the advantages of RNA sequencing (RNA-Seq) over microarrays, it
is gaining widespread popularity for highly parallel gene expression analysis. For example, …
is gaining widespread popularity for highly parallel gene expression analysis. For example, …