The contribution of molecular alterations in bone marrow mesenchymal stromal cells (BM-MSC)
to the pathogenesis of acute myeloid leukemia (AML) is poorly understood. Thus we …

Activated SUMOylation is a hallmark of cancer. Starting from a targeted screening for SUMO-regulated
immune evasion mechanisms, we identified an evolutionarily conserved function …

1 Grimwade D, Ivey A, Huntly BJ. Molecular landscape of acute myeloid leukemia in younger
adults and its clinical relevance. Blood 2016; 127: 29–42. 2 Xie M, Lu C, Wang J, McLellan …

Chromosomal rearrangements and specific aneuploidy patterns are initiating events and
define subgroups in B-cell precursor acute lymphoblastic leukemia (BCP-ALL). Here we …

Recent efforts reclassified B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) into
more refined subtypes. Nevertheless, outcomes of relapsed BCP-ALL remain unsatisfactory, …

Background Long non-coding RNAs (lncRNAs) have emerged as a novel class of RNA due
to its diverse mechanism in cancer development and progression. However, the role and …

Background GATA3 is pivotal for the development of T lymphocytes. While its effects in later
stages of T cell differentiation are well recognized, the role of GATA3 in the generation of …

Aberrant CXCR4 activity has been implicated in lymphoma pathogenesis, disease
progression, and resistance to therapies. Using a mouse model with a gain-of-function CXCR4 …

FAT atypical cadherin 1 (FAT1), a transmembrane protein, is frequently mutated in various
cancer types and has been described as context-dependent tumor suppressor or oncogene. …

The DNA damage response (DDR) acts as a barrier to malignant transformation and is often
impaired during tumorigenesis. Exploiting the impaired DDR can be a promising …