Intratumoral heterogeneity in cancers arises from genomic instability and epigenomic plasticity
and is associated with resistance to cytotoxic and targeted therapies. We show here that …

The identification of the molecular drivers of cancer by sequencing is the backbone of
precision medicine and the basis of personalized therapy; however, biopsies of primary tumors …

Perturbation biology is a powerful approach to modeling quantitative cellular behaviors and
understanding detailed disease mechanisms. However, large-scale protein response …

Signaling networks downstream of receptor tyrosine kinases are among the most
extensively studied biological networks, but new approaches are needed to elucidate causal …

Pathological complete response (pCR) is an accurate predictor of good outcome following
neoadjuvant chemotherapy (NAC) for locally advanced breast cancer. The presence of …

To build a catalog of peptides presented by breast cancer cells, we undertook systematic
MHC class I immunoprecipitation followed by elution of MHC class I-loaded peptides in breast …

Many emerging technologies are reliant on circulating cell-free DNA (cfDNA) and cell-free
RNA (cfRNA) applications in the clinic. However, the impact of diurnal cycles or daily meals on …

Background:Cancer health research relies on large-scale cohorts to derive generalizable
results for different populations. While traditional epidemiological cohorts often use costly …

The Healthy Oregon Project (HOP) is a statewide effort that aims to build a large research
repository and influence the health of Oregonians through providing no-cost genetic screening …

Methods Participants were recruited into HOP in three tiered phases beginning in 2018
through diverse recruitment strategies. All enrollment into the study, and all informed consent, …