The RESOLUTE consortium: unlocking SLC transporters for drug discovery
…, E Girardi, U Goldmann, B Gürtl, K Klavins… - Nature reviews Drug …, 2020 - nature.com
The Innovative Medicines Initiative Consortium RESOLUTE has started to develop tools and
produce data sets to de-orphanize transporters in the solute carrier protein (SLC) …
produce data sets to de-orphanize transporters in the solute carrier protein (SLC) …
[HTML][HTML] A review of recent advances in natural polymer-based scaffolds for musculoskeletal tissue engineering
…, M Ghorbani, F Rastegar Adib, Z Ghasemi, K Klavins… - Polymers, 2022 - mdpi.com
The musculoskeletal (MS) system consists of bone, cartilage, tendon, ligament, and skeletal
muscle, which forms the basic framework of the human body. This system plays a vital role …
muscle, which forms the basic framework of the human body. This system plays a vital role …
Metabolic network failures in Alzheimer's disease: A biochemical road map
Introduction The Alzheimer's Disease Research Summits of 2012 and 2015 incorporated
experts from academia, industry, and nonprofit organizations to develop new research …
experts from academia, industry, and nonprofit organizations to develop new research …
[HTML][HTML] Harmonizing lipidomics: NIST interlaboratory comparison exercise for lipidomics using SRM 1950–Metabolites in Frozen Human Plasma [S]
…, J Jiang, M Kachman, R Kiyonami, K Klavins… - Journal of lipid …, 2017 - ASBMB
As the lipidomics field continues to advance, self-evaluation within the community is critical.
Here, we performed an interlaboratory comparison exercise for lipidomics using Standard …
Here, we performed an interlaboratory comparison exercise for lipidomics using Standard …
[HTML][HTML] Systems-level organization of yeast methylotrophic lifestyle
…, K Grillitsch, G Modarres, R Guerrasio, K Klavins… - BMC biology, 2015 - Springer
Background Some yeasts have evolved a methylotrophic lifestyle enabling them to utilize
the single carbon compound methanol as a carbon and energy source. Among them, Pichia …
the single carbon compound methanol as a carbon and energy source. Among them, Pichia …
Blood metabolite markers of preclinical Alzheimer's disease in two longitudinally followed cohorts of older individuals
…, M Griswold, D Sonntag, J Wahrheit, K Klavins… - Alzheimer's & …, 2016 - Elsevier
… g , Michael Griswold h , Denise Sonntag i , Judith Wahrheit i , Kristaps Klavins i , Palmi V.
Jonsson j , Gudny Eiriksdottir k , Thor Aspelund j k , Lenore J. Launer l , Vilmundur Gudnason j …
Jonsson j , Gudny Eiriksdottir k , Thor Aspelund j k , Lenore J. Launer l , Vilmundur Gudnason j …
[HTML][HTML] Mucosal biofilms are an endoscopic feature of irritable bowel syndrome and ulcerative colitis
…, S Strohmaier, C Primas, W Dolak, T Köcher, K Klavins… - Gastroenterology, 2021 - Elsevier
Background & Aims Irritable bowel syndrome (IBS) and inflammatory bowel diseases result
in a substantial reduction in quality of life and a considerable socioeconomic impact. In IBS, …
in a substantial reduction in quality of life and a considerable socioeconomic impact. In IBS, …
[HTML][HTML] Metabolomics in bone research
Identifying the changes in endogenous metabolites in response to intrinsic and extrinsic
factors has excellent potential to obtain an understanding of cells, biofluids, tissues, or …
factors has excellent potential to obtain an understanding of cells, biofluids, tissues, or …
[HTML][HTML] Trained immunity of alveolar macrophages requires metabolic rewiring and type 1 interferon signaling
…, F Oberndorfer, C Lassnig, B Strobl, K Klavins… - Mucosal …, 2022 - nature.com
Environmental microbial triggers shape the development and functionality of the immune
system. Alveolar macrophages (AMs), tissue-resident macrophages of the lungs, are in …
system. Alveolar macrophages (AMs), tissue-resident macrophages of the lungs, are in …
Amino acid metabolism is significantly altered at the time of admission in hospital for severe COVID-19 patients: findings from longitudinal targeted metabolomics …
…, L Viksna, O Kolesova, K Klavins… - Microbiology …, 2021 - Am Soc Microbiol
The heterogeneity in severity and outcome of COVID-19 cases points out the urgent need
for early molecular characterization of patients followed by risk-stratified care. The main …
for early molecular characterization of patients followed by risk-stratified care. The main …