Studies examining the inheritance of inflammatory bowel disease (IBD) within different
family groups have been the basis for recent molecular advances in the genetics of IBD. The …

The cardiac ryanodine receptor (RyR2), the major calcium release channel on the sarcoplasmic
reticulum (SR) in cardiomyocytes, has recently been shown to be involved in at least two …

Urban living in built environments, combined with the use of processed water and food, may
not provide the microbial stimulation necessary for a balanced development of immune …

Background—Familial polymorphic ventricular tachycardia is an autosomal-dominant, inherited
disease with a relatively early onset and a mortality rate of ≈30% by the age of 30 years. …

Background The ε4 allele of apolipoprotein E has been associated with an increased risk of
late-onset Alzheimer's disease. In a cohort of elderly subjects we prospectively investigated …

OBJECTIVES The purpose of this study was to provide clinical and anatomical characteristics
as well as genetic background of a malignant arrhythmogenic disorder. BACKGROUND …

The QT interval, an electrocardiographic measure reflecting myocardial repolarization, is a
heritable trait. QT prolongation is a risk factor for ventricular arrhythmias and sudden cardiac …

We describe a new technique by which single base changes in human genes can be
conveniently detected. In this method the DNA fragment of interest is first amplified using the …

Primary sclerosing cholangitis (PSC) is a rare progressive disorder leading to bile duct
destruction; ∼75% of patients have comorbid inflammatory bowel disease (IBD). We undertook …

Long QT syndrome (LQTS) is caused by functional alterations in cardiac ion channels and
is associated with prolonged cardiac repolarization time and increased risk of ventricular …