Here we investigated the potential role of bone-resorbing osteoclasts in homeostasis and
stress-induced mobilization of hematopoietic progenitors. Different stress situations induced …

Hematopoietic stem and progenitor cells (HSPCs) continuously egress out of the bone marrow
(BM) to the circulation under homeostatic conditions. Their enhanced recruitment to the …

Technological forecasting is now poised to respond to the emerging needs of private and
public sector organizations in the highly competitive global environment. The history of the …

The mechanisms of hematopoietic progenitor cell egress and clinical mobilization are not
fully understood. Herein, we report that in vivo desensitization of Sphingosine-1-phosphate (…

Steady-state egress of hematopoietic progenitor cells can be rapidly amplified by mobilizing
agents such as AMD3100, the mechanism, however, is poorly understood. We report that …

We develop an optical whole-body imaging technique for monitoring normal and leukemic
hematopoietic cell homing in vivo. A recently developed near-infrared (NIR) lipophilic …

Multiple mechanisms promote tumor prosperity, which does not only depend on cell-autonomous,
inherent abnormal characteristics of the malignant cells that facilitate rapid cell …

The CD45 phosphatase is uniquely expressed by all leukocytes, but its role in regulating
hematopoietic progenitors is poorly understood. We show that enhanced CD45 expression on …

Lipids have the potential to serve as bio-markers, which allow us to analyze and to identify
cells under various experimental settings, and to serve as a clinical diagnostic tool. For …

The hallmark of hematopoietic stem and progenitor cells (HSPCs) is their motility, which is
essential for their function, such as recruitment upon demand. Stromal Derived Factor-1 (SDF-…