… Clotting factor II, or prothrombin, is a vitamin K-dependent coagulation cofactor that is … in
severe liver disease, vitamin K deficiency, or vitamin K antagonist treatment. In these cases, …

Hemophagocytic syndrome (HPS) is characterized by an uncontrolled and poorly understood
activation of T-helper 1 (Th-1) lymphocytes and macrophages. We studied 20 patients with …

IgG4-related systemic disease is now recognized as a systemic disease that may affect
various organs. The diagnosis is usually made in patients who present with elevated IgG4 in …

… Grados, Aurélie MD; Ebbo, Mikael MD; Bernit, Emmanuelle MD; Veit, Véronique MD;
Mazodier, Karin MD; Jean, Rodolphe MD; Coso, Diane MD; Aurran-Schleinitz, Thérèse MD; …

Around the tenth day after diagnosis, ∼20% of patients with coronavirus disease 2019 (COVID-19)−associated
pneumonia evolve toward severe oxygen dependence (stage 2b) and …

Objective Blood concentrations of hydroxychloroquine (HCQ) vary widely among patients
with systemic lupus erythematosus (SLE). A pharmacokinetic/pharmacodynamic relationship …

Objective. Cardiac involvement during systemic lupus erythematosus (SLE) may include the
pericardium, myocardium, valvular tissue, and coronary arteries. The aim of this study was …

Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening condition due to the association
of an infectious agent with lymphocyte cytotoxicity defects, either of congenital genetic …

Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory condition.
Primary HLH occurs early in life as a result of monogenic biallelic mutations affecting …

Despite the rapid discovery of genes for rare genetic disorders, we continue to encounter
individuals presenting with syndromic manifestations. Here, we have studied four affected …