Background Molecular diagnostics are considered the most promising route to achievement
of rapid, universal drug susceptibility testing for Mycobacterium tuberculosis complex (MTBC…

… experiments resulted in correct identification of the H57D mutation in pncA that confers
pyrazinamide resistance in BCG, but in the 5% spike, this call was filtered out as it only had k-mer …

… In the limit in which the dissociation constant K d (= k off /(p T k on )) is very small compared
to z, we obtain that the main effect of retroactivity is to increase the point of half maximal …

Cells of Sphingomonas sp. strain BSAR-1 constitutively expressed an alkaline phosphatase,
which was also secreted in the extracellular medium. A null mutant lacking this alkaline …

Background Bedaquiline is a core drug for the treatment of multidrug-resistant tuberculosis;
however, the understanding of resistance mechanisms is poor, which is hampering rapid …

Background Early and accurate diagnosis of tuberculosis is a priority for TB programs globally
to initiate treatment early and improve treatment outcomes. Currently, Ziehl–Neelsen (ZN) …

Background Multidrug-resistant (MDR) Mycobacterium tuberculosis complex (MTBC) strains
are a serious health problem in India, also contributing to one-fourth of the global MDR …

Amplification of drug resistance in Mycobacterium tuberculosis (M.tb) and its transmission
are significant barriers in controlling tuberculosis (TB) globally. Diagnostic inaccuracies and …

In the current study, ceftazidime- and ciprofloxacin-resistant—or dual drug-resistant (DDR)—E.
coli were isolated from river Mula-Mutha, which flows through rural Pune district and …

Universal access to drug susceptibility testing for newly diagnosed tuberculosis patients is
recommended. Access to culture-based diagnostics remains limited, and targeted molecular …