… Moreover, the K ATP channel encoded by dSUR protects the heart against hypoxia/… The
potential for discovery of new genes, such as the two-pore ORK1 K + channel that affects heart …

… We review here the evidence for an involvement of the insulin-TOR pathway, the K ATP
channel subunit dSur, the KCNQ potassium channel, as well as Dystrophin and Myosin in fly …

Sestrins are conserved proteins that accumulate in cells exposed to stress, potentiate
adenosine monophosphate–activated protein kinase (AMPK), and inhibit activation of target of …

… role for K + channels was suggested in that channel blockers such as TEA caused dramatic
reductions in heart rate [21] and mutations in shaker, ether-a-gogo and slowpoke K + …

High-fat-diet (HFD)-induced obesity is a major contributor to diabetes and cardiovascular
disease, but the underlying genetic mechanisms are poorly understood. Here, we use …

… Inset shows the enlargement of the boxed area in k–o at the AVC. A, atrium; V, ventricle. …
i–p, notch1b (i–l) and deltaD (m–p) in situ hybridization on control (i, k, m, o) or ablated (j, l, n, p) …

Heart diseases are the most common causes of morbidity and death in humans. Using
cardiac-specific RNAi-silencing in Drosophila, we knocked down 7061 evolutionarily conserved …

The genetic basis of heart development is remarkably conserved from Drosophila to
mammals, and insights from flies have greatly informed our understanding of vertebrate heart …

… , which encodes a subunit of a K + channel responsible for the slower repolarizing current
(I Ks ) (for reviews, see refs. 11–13). Mutations in these K + channels commonly lead to a loss …

… (K) Heart period was increased in chico 1 /+ mutants fed with an LSD or HSD. Heart period
of … (K) Systole did not change in heart specific knockdown of GFAT or OGT flies raised on an …