User profiles for K. Ouararhni
 | khalid OuararhniIGBMC Verified email at igbmc.fr Cited by 2573 |
[HTML][HTML] The epigenetic integrator UHRF1: on the road to become a universal biomarker for cancer
…, A Ibrahim, M Alhosin, L Zaayter, K Ouararhni… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Cancer is one of the deadliest diseases in the world causing record number of mortalities in
both developed and undeveloped countries. Despite a lot of advances and breakthroughs in …
both developed and undeveloped countries. Despite a lot of advances and breakthroughs in …
The death-associated protein DAXX is a novel histone chaperone involved in the replication-independent deposition of H3. 3
P Drané, K Ouararhni, A Depaux, M Shuaib… - Genes & …, 2010 - genesdev.cshlp.org
The histone variant H3.3 marks active chromatin by replacing the conventional histone H3.1.
In this study, we investigate the detailed mechanism of H3.3 replication-independent …
In this study, we investigate the detailed mechanism of H3.3 replication-independent …
ANP32E is a histone chaperone that removes H2A. Z from chromatin
…, K Ouararhni, C Papin, ML Diebold, K Padmanabhan… - Nature, 2014 - nature.com
H2A.Z is an essential histone variant implicated in the regulation of key nuclear events.
However, the metazoan chaperones responsible for H2A.Z deposition and its removal from …
However, the metazoan chaperones responsible for H2A.Z deposition and its removal from …
Transcription cofactors TRIM24, TRIM28, and TRIM33 associate to form regulatory complexes that suppress murine hepatocellular carcinoma
…, K Ouararhni, K Khetchoumian… - Proceedings of the …, 2011 - National Acad Sciences
TRIM24 (TIF1α), TRIM28 (TIF1β), and TRIM33 (TIF1γ) are three related cofactors belonging
to the tripartite motif superfamily that interact with distinct transcription factors. TRIM24 …
to the tripartite motif superfamily that interact with distinct transcription factors. TRIM24 …
HJURP binds CENP-A via a highly conserved N-terminal domain and mediates its deposition at centromeres
M Shuaib, K Ouararhni, S Dimitrov… - Proceedings of the …, 2010 - National Acad Sciences
The human histone H3 variant, CENP-A, replaces the conventional histone H3 in centromeric
chromatin and, together with centromere-specific DNA-binding factors, directs the …
chromatin and, together with centromere-specific DNA-binding factors, directs the …
The histone variant mH2A1. 1 interferes with transcription by down-regulating PARP-1 enzymatic activity
K Ouararhni, R Hadj-Slimane, S Ait-Si-Ali… - Genes & …, 2006 - genesdev.cshlp.org
The histone variant mH2A is believed to be involved in transcriptional repression, but how it
exerts its function remains elusive. By using chromatin immunoprecipitation and tandem …
exerts its function remains elusive. By using chromatin immunoprecipitation and tandem …
[PDF][PDF] The flexible ends of CENP-A nucleosome are required for mitotic fidelity
Y Roulland, K Ouararhni, M Naidenov, L Ramos… - Molecular cell, 2016 - cell.com
CENP-A is a histone variant, which replaces histone H3 at centromeres and confers unique
properties to centromeric chromatin. The crystal structure of CENP-A nucleosome suggests …
properties to centromeric chromatin. The crystal structure of CENP-A nucleosome suggests …
[HTML][HTML] Prognostic tools and candidate drugs based on plasma proteomics of patients with severe COVID-19 complications
…, RMA Aly, M Al Maslamani, K Ouararhni… - Nature …, 2022 - nature.com
COVID-19 complications still present a huge burden on healthcare systems and warrant
predictive risk models to triage patients and inform early intervention. Here, we profile 893 …
predictive risk models to triage patients and inform early intervention. Here, we profile 893 …
Molecular basis and specificity of H2A. Z–H2B recognition and deposition by the histone chaperone YL1
… 1g), and we measured a K d of 4.4 nM between the YL1 ZID and H2A.Z–H2B dimers (Fig. …
N94D, which showed a K d of 5.6 nM, a value almost identical to the K d of 4.4 nM observed for …
N94D, which showed a K d of 5.6 nM, a value almost identical to the K d of 4.4 nM observed for …
The TIF1α-related TRIM cofactors couple chromatin modifications to transcriptional regulation, signaling and tumor suppression
B Herquel, K Ouararhni, I Davidson - Transcription, 2011 - Taylor & Francis
TRIM24 (TIF1α), TRIM28 (TIF1β) and TRIM33 (TIF1γ) are related cofactors defining a subgroup
of the tripartite motif (TRIM) superfamily comprising an N-terminal RING finger E3 ligase …
of the tripartite motif (TRIM) superfamily comprising an N-terminal RING finger E3 ligase …