User profiles for K. Petkevicius
Kasparas Petkevicius"Springboard to Independence" researcher, MRC Mitochondrial biology unit Verified email at mrc-mbu.cam.ac.uk Cited by 588 |
[HTML][HTML] Insect sex pheromone production in yeasts and plants
K Petkevicius, C Löfstedt, I Borodina - Current Opinion in Biotechnology, 2020 - Elsevier
Insect infestation is a major problem in agriculture and forestry addressed primarily with
insecticide sprays or genetically modified plant breeds. The problem has aggravated in the last …
insecticide sprays or genetically modified plant breeds. The problem has aggravated in the last …
Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages
K Clark, KF MacKenzie, K Petkevicius… - Proceedings of the …, 2012 - National Acad Sciences
Macrophages acquire strikingly different properties that enable them to play key roles
during the initiation, propagation, and resolution of inflammation. Classically activated (M1) …
during the initiation, propagation, and resolution of inflammation. Classically activated (M1) …
[PDF][PDF] Chronic activation of γ2 AMPK induces obesity and reduces β cell function
Despite significant advances in our understanding of the biology determining systemic
energy homeostasis, the treatment of obesity remains a medical challenge. Activation of AMP-…
energy homeostasis, the treatment of obesity remains a medical challenge. Activation of AMP-…
SREBP1-induced fatty acid synthesis depletes macrophages antioxidant defences to promote their alternative activation
G Bidault, S Virtue, K Petkevicius, HE Jolin… - Nature …, 2021 - nature.com
Macrophages exhibit a spectrum of activation states ranging from classical to alternative
activation 1 . Alternatively, activated macrophages are involved in diverse pathophysiological …
activation 1 . Alternatively, activated macrophages are involved in diverse pathophysiological …
[HTML][HTML] Production of moth sex pheromones for pest control by yeast fermentation
…, BJ Ding, HL Wang, MI Dam, K Petkevicius… - Metabolic …, 2020 - Elsevier
The use of insect sex pheromones is an alternative technology for pest control in agriculture
and forestry, which, in contrast to insecticides, does not have adverse effects on human …
and forestry, which, in contrast to insecticides, does not have adverse effects on human …
Accelerated phosphatidylcholine turnover in macrophages promotes adipose tissue inflammation in obesity
10.7554/eLife.47990.001 White adipose tissue (WAT) inflammation contributes to the
development of insulin resistance in obesity. While the role of adipose tissue macrophage (ATM) …
development of insulin resistance in obesity. While the role of adipose tissue macrophage (ATM) …
Bone morphogenetic protein 8B promotes the progression of non-alcoholic steatohepatitis
…, D Tiniakos, S Snow, S Davies, K Petkevicius… - Nature …, 2020 - nature.com
… , Relative mRNA expression levels (whole-liver RNA; resected livers from the same mice
were used as ‘day 0’ reference) of genes measured by RTqPCR (j) and IPA analysis (k; NGS) …
were used as ‘day 0’ reference) of genes measured by RTqPCR (j) and IPA analysis (k; NGS) …
[HTML][HTML] Sphingosine 1-phosphate mediates adiponectin receptor signaling essential for lipid homeostasis and embryogenesis
…, D Kaper, M Henricsson, A Nik, K Petkevicius… - Nature …, 2022 - nature.com
Cells and organisms require proper membrane composition to function and develop.
Phospholipids are the major component of membranes and are primarily acquired through the diet. …
Phospholipids are the major component of membranes and are primarily acquired through the diet. …
[PDF][PDF] Peroxisome proliferator-activated receptor γ2 controls the rate of adipose tissue lipid storage and determines metabolic flexibility
S Virtue, K Petkevicius, JM Moreno-Navarrete… - Cell Reports, 2018 - cell.com
One understudied function of white adipose tissue (AT) is its role in postprandial lipid buffering.
In this study, we demonstrate that mice lacking the adipose tissue-specific transcription …
In this study, we demonstrate that mice lacking the adipose tissue-specific transcription …
[HTML][HTML] TLCD1 and TLCD2 regulate cellular phosphatidylethanolamine composition and promote the progression of non-alcoholic steatohepatitis
The fatty acid composition of phosphatidylethanolamine (PE) determines cellular metabolism,
oxidative stress, and inflammation. However, our understanding of how cells regulate PE …
oxidative stress, and inflammation. However, our understanding of how cells regulate PE …