Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa
…, KB Hanscombe, KL Purves… - Nature …, 2019 - nature.com
Characterized primarily by a low body-mass index, anorexia nervosa is a complex and
serious illness 1 , affecting 0.9–4% of women and 0.3% of men 2 , 3 – 4 , with twin-based …
serious illness 1 , affecting 0.9–4% of women and 0.3% of men 2 , 3 – 4 , with twin-based …
Genetic contributions to anxiety disorders: where we are and where we are heading
Anxiety disorders are among the most common psychiatric disorders worldwide. They often
onset early in life, with symptoms and consequences that can persist for decades. This …
onset early in life, with symptoms and consequences that can persist for decades. This …
A major role for common genetic variation in anxiety disorders
Anxiety disorders are common, complex psychiatric disorders with twin heritabilities of 30–60%.
We conducted a genome-wide association study of Lifetime Anxiety Disorder (n case = …
We conducted a genome-wide association study of Lifetime Anxiety Disorder (n case = …
Multimodal neuroimaging of frontolimbic structure and function associated with suicide attempts in adolescents and young adults with bipolar disorder
…, ET Cox Lippard, KL Purves… - American journal of …, 2017 - Am Psychiatric Assoc
Objective: Bipolar disorder is associated with high risk for suicidal behavior that often develops
in adolescence and young adulthood. Elucidation of involved neural systems is critical for …
in adolescence and young adulthood. Elucidation of involved neural systems is critical for …
Genetic variants associated with anxiety and stress-related disorders: a genome-wide association study and mouse-model study
Importance Anxiety and stress-related disorders are among the most common mental
disorders. Although family and twin studies indicate that both genetic and environmental factors …
disorders. Although family and twin studies indicate that both genetic and environmental factors …
Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank
Depression is more frequent among individuals exposed to traumatic events. Both trauma
exposure and depression are heritable. However, the relationship between these traits, …
exposure and depression are heritable. However, the relationship between these traits, …
Genomics of body fat percentage may contribute to sex bias in anorexia nervosa
Anorexia nervosa (AN) occurs nine times more often in females than in males. Although
environmental factors likely play a role, the reasons for this imbalanced sex ratio remain …
environmental factors likely play a role, the reasons for this imbalanced sex ratio remain …
[HTML][HTML] Genetic correlations of psychiatric traits with body composition and glycemic traits are sex-and age-dependent
Body composition is often altered in psychiatric disorders. Using genome-wide common
genetic variation data, we calculate sex-specific genetic correlations amongst body fat %, fat …
genetic variation data, we calculate sex-specific genetic correlations amongst body fat %, fat …
[HTML][HTML] Using molecular networking for microbial secondary metabolite bioprospecting
K Purves, L Macintyre, D Brennan, GÓ Hreggviðsson… - Metabolites, 2016 - mdpi.com
… , Kevin Purves and Katherine R. Duncan organized and conducted sediment sampling,
Kevin Purves isolated and sub-cultured pure colonies from isolation plates. Kevin Purves and …
Kevin Purves isolated and sub-cultured pure colonies from isolation plates. Kevin Purves and …
[HTML][HTML] Measuring fear: Association among different measures of fear learning.
Background and objectives Fear conditioning paradigms use various measures to assess
learned fear, including autonomic arousal responses like skin conductance, and self-reports of …
learned fear, including autonomic arousal responses like skin conductance, and self-reports of …