User profiles for K. R. Kodella

Konstantia R Kodella

Scientist, Cellarity
Verified email at cellarity.com
Cited by 715

Reproducing human and cross-species drug toxicities using a Liver-Chip

…, J Ronxhi, HK Lim, L Ewart, KR Kodella… - Science translational …, 2019 - science.org
Nonclinical rodent and nonrodent toxicity models used to support clinical trials of candidate
drugs may produce discordant results or fail to predict complications in humans, contributing …

[HTML][HTML] Modeling alpha-synuclein pathology in a human brain-chip to assess blood-brain barrier disruption

I Pediaditakis, KR Kodella, DV Manatakis, CY Le… - Nature …, 2021 - nature.com
Parkinson’s disease and related synucleinopathies are characterized by the abnormal
accumulation of alpha-synuclein aggregates, loss of dopaminergic neurons, and gliosis of the …

[PDF][PDF] A microengineered Brain-Chip to model neuroinflammation in humans

I Pediaditakis, KR Kodella, DV Manatakis, CY Le… - Iscience, 2022 - cell.com
Species differences in brain and blood–brain barrier (BBB) biology hamper the translation of
findings from animal models to humans, impeding the development of therapeutics for brain …

Modeling Alpha-synuclein pathology in a human brain-chip to assess blood-brain barrier disruption in Parkinson's disease

I Pediaditakis, KR Kodella, DV Manatakis, CD Hinojosa… - BioRxiv, 2020 - biorxiv.org
Parkinson’s disease and related synucleinopathies are characterized by the abnormal
accumulation of alpha-synuclein aggregates, loss of dopaminergic neurons, and gliosis in the …

Effects of radiation absorption and aligned magnetic field on MHD Cassion fluid past an inclined vertical porous plate in porous media

R Kodi, RR Vaddemani… - Simulation and Analysis of …, 2021 - Wiley Online Library
This article analyses the magnetic field, substance and therapeutic utility effects, the study‐Absolute
convective motions of a viscous, impenetrable, and electrically regulated fluid …

Cardioprotective effect of a dual acting epoxyeicosatrienoic acid analogue towards ischaemia reperfusion injury

…, KR Chaudhary, H El‐Sikhry, R Kodela… - British journal of …, 2011 - Wiley Online Library
KR Chaudhary… KR Chaudhary … KR Chaudhary …

Heat source/sink effects on convective flow of a Newtonian fluid past an inclined vertical plate in conducting field

R Kodi, O Mopuri - … and Analysis of Mathematical Methods in …, 2021 - Wiley Online Library
… Figure 6.7 indicates the velocity influence of the parameter chemical reaction, as the velocity
decreases with the rise in the Kr chemical reaction parameter. In Figure 6.8, we can see that …

Three new ingol diterpenes from Euphorbia nivulia: evaluation of cytotoxic activity.

…, VLN Reddy, AV Reddy, KR Kodela Ravinder… - 2003 - cabidigitallibrary.org
The latex of E. nivulia (collected from Bhadrachalam forest, Andhra Pradesh, India, in
January 2000) afforded three new ingol diterpenes, 3-acetyl-8-methoxyl-7-angolyl-12-…

NOSH–aspirin (NBS-1120), a novel nitric oxide-and hydrogen sulfide-releasing hybrid is a potent inhibitor of colon cancer cell growth in vitro and in a xenograft mouse …

M Chattopadhyay, R Kodela, KR Olson… - … and biophysical research …, 2012 - Elsevier
Nonsteroidal anti-inflammatory drugs (NSAIDs) are prototypical anti-cancer agents. However,
their long-term use is associated with adverse gastrointestinal effects. Recognition that …

14, 15-Epoxyeicosa-5, 8, 11-trienoic acid (14, 15-EET) surrogates containing epoxide bioisosteres: influence upon vascular relaxation and soluble epoxide hydrolase …

JR Falck, R Kodela, R Manne, KR Atcha… - Journal of medicinal …, 2009 - ACS Publications
All-cis-14,15-epoxyeicosa-5,8,11-trienoic acid (14,15-EET) is a labile, vasodilatory eicosanoid
generated from arachidonic acid by cytochrome P450 epoxygenases. A series of robust, …