[HTML][HTML] Pioneer and nonpioneer factor cooperation drives lineage specific chromatin opening
A Mayran, K Sochodolsky, K Khetchoumian… - Nature …, 2019 - nature.com
Pioneer transcription factors are characterized by having the unique property of enabling the
opening of closed chromatin sites, for implementation of cell fates. We previously found that …
opening of closed chromatin sites, for implementation of cell fates. We previously found that …
[HTML][HTML] Transcription factor GATA2 may potentiate follicle-stimulating hormone production in mice via induction of the BMP antagonist gremlin in gonadotrope cells
G Schang, L Ongaro, E Brûlé, X Zhou, Y Wang… - Journal of Biological …, 2022 - ASBMB
Mammalian reproduction depends on the gonadotropins, follicle-stimulating hormone (FSH),
and luteinizing hormone, which are secreted by pituitary gonadotrope cells. The zinc-finger …
and luteinizing hormone, which are secreted by pituitary gonadotrope cells. The zinc-finger …
Unraveling the mysteries of PAX8 in reproductive tract cancers
D Chaves-Moreira, PJ Morin, R Drapkin - Cancer research, 2021 - AACR
Paired Box 8 (PAX8) is a lineage-specific transcription factor that has essential roles during
embryogenesis and tumorigenesis. The importance of PAX8 in the development of the …
embryogenesis and tumorigenesis. The importance of PAX8 in the development of the …
Reciprocal stabilization of transcription factor binding integrates two signaling pathways to regulate fission yeast fbp1 transcription
…, T Abe, CS Hoffman, K Hirota - Nucleic Acids …, 2021 - academic.oup.com
Transcriptional regulation, a pivotal biological process by which cells adapt to environmental
fluctuations, is achieved by the binding of transcription factors to target sequences in a …
fluctuations, is achieved by the binding of transcription factors to target sequences in a …
Chromatin opening ability of pioneer factor Pax7 depends on unique isoform and C-terminal domain
V Bascunana, A Pelletier, A Gouhier… - Nucleic Acids …, 2023 - academic.oup.com
Pioneer factors are transcription factors (TFs) that have the unique ability to recognise their
target DNA sequences within closed chromatin. Whereas their interactions with cognate DNA …
target DNA sequences within closed chromatin. Whereas their interactions with cognate DNA …
Pax7 pioneer factor action requires both paired and homeo DNA binding domains
A Pelletier, A Mayran, A Gouhier… - Nucleic Acids …, 2021 - academic.oup.com
The pioneer transcription factor Pax7 contains two DNA binding domains (DBD), a paired
and a homeo domain. Previous work on Pax7 and the related Pax3 showed that each DBD …
and a homeo domain. Previous work on Pax7 and the related Pax3 showed that each DBD …
Pre-marked chromatin and transcription factor co-binding shape the pioneering activity of Foxa2
…, S Hasenöder, Z Wang, K Scheibner… - Nucleic Acids …, 2019 - academic.oup.com
Pioneer transcription factors (PTF) can recognize their binding sites on nucleosomal DNA
and trigger chromatin opening for recruitment of other non-pioneer transcription factors. …
and trigger chromatin opening for recruitment of other non-pioneer transcription factors. …
A new perspective on regulation of pituitary plasticity: the network of SOX2-positive cells may coordinate responses to challenge
PR Le Tissier, JF Murray, P Mollard - Endocrinology, 2022 - academic.oup.com
Plasticity of function is required for each of the anterior pituitary endocrine axes to support
alterations in the demand for hormone with physiological status and in response to …
alterations in the demand for hormone with physiological status and in response to …
Steroidogenic factor 1 regulates transcription of the inhibin B coreceptor in pituitary gonadotrope cells
YF Lin, G Schang, ERS Buddle, H Schultz… - …, 2022 - academic.oup.com
The inhibins control reproduction by suppressing follicle-stimulating hormone synthesis in
pituitary gonadotrope cells. The newly discovered inhibin B coreceptor, TGFBR3L, is …
pituitary gonadotrope cells. The newly discovered inhibin B coreceptor, TGFBR3L, is …
Structures and consequences of pioneer factor binding to nucleosomes
E Luzete-Monteiro, KS Zaret - Current opinion in structural biology, 2022 - Elsevier
Pioneer transcription factors are able to bind a partially exposed motif on the surface of a
nucleosome, enabling the proteins to target sites in silent regions of chromatin that have been …
nucleosome, enabling the proteins to target sites in silent regions of chromatin that have been …