Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants
…, S Kathiresan, MA Ikram, R McPherson, K Stefansson… - Stroke, 2014 - Am Heart Assoc
Background and Purpose— Ischemic stroke (IS) and coronary artery disease (CAD) share
several risk factors and each has a substantial heritability. We conducted a genome-wide …
several risk factors and each has a substantial heritability. We conducted a genome-wide …
A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip
…, AG Uitterlinden, I Jonsdottir, K Stefansson… - Annals of the …, 2014 - ard.bmj.com
Objectives Osteoarthritis (OA) is the most common form of arthritis with a clear genetic component.
To identify novel loci associated with hip OA we performed a meta-analysis of genome…
To identify novel loci associated with hip OA we performed a meta-analysis of genome…
Biological insights from 108 schizophrenia-associated genetic loci
Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of
alleles, including common alleles of small effect that might be detected by genome-wide …
alleles, including common alleles of small effect that might be detected by genome-wide …
Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease
…, S Steinberg, H Stefansson, K Stefansson… - Nature …, 2011 - nature.com
We sought to identify new susceptibility loci for Alzheimer's disease through a staged
association study (GERAD+) and by testing suggestive loci reported by the Alzheimer's Disease …
association study (GERAD+) and by testing suggestive loci reported by the Alzheimer's Disease …
[HTML][HTML] Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study
…, D Ardissino, D Siscovick, R Elosua, K Stefansson… - The Lancet, 2012 - thelancet.com
Background High plasma HDL cholesterol is associated with reduced risk of myocardial
infarction, but whether this association is causal is unclear. Exploiting the fact that genotypes are …
infarction, but whether this association is causal is unclear. Exploiting the fact that genotypes are …
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
Genome-wide association (GWA) studies have identified multiple loci at which common variants
modestly but reproducibly influence risk of type 2 diabetes (T2D) 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , …
modestly but reproducibly influence risk of type 2 diabetes (T2D) 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , …
Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes
…, U Thorsteinsdottir, JR Gulcher, A Kong, K Stefansson - Nature …, 2006 - nature.com
We have previously reported suggestive linkage of type 2 diabetes mellitus to chromosome
10q 1 . We genotyped 228 microsatellite markers in Icelandic individuals with type 2 …
10q 1 . We genotyped 228 microsatellite markers in Icelandic individuals with type 2 …
Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder
…, JY Tung, ID Waldman, SE Medland, K Stefansson… - Nature …, 2019 - nature.com
Attention deficit/hyperactivity disorder (ADHD) is a highly heritable childhood behavioral
disorder affecting 5% of children and 2.5% of adults. Common genetic variants contribute …
disorder affecting 5% of children and 2.5% of adults. Common genetic variants contribute …
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
To extend understanding of the genetic architecture and molecular basis of type 2 diabetes (T2D),
we conducted a meta-analysis of genetic variants on the Metabochip, including …
we conducted a meta-analysis of genetic variants on the Metabochip, including …
Large recurrent microdeletions associated with schizophrenia
…, L Peltonen, DA Collier, D St Clair, K Stefansson - nature, 2008 - nature.com
Reduced fecundity, associated with severe mental disorders 1 , places negative selection
pressure on risk alleles and may explain, in part, why common variants have not been found …
pressure on risk alleles and may explain, in part, why common variants have not been found …