Accumulating evidence suggests that oxidative stress plays a major role in the pathogenesis
of multiple sclerosis (MS). Reactive oxygen species (ROS), which if produced in excess …

… Correspondence should be addressed to Klaus Tenbrock, ktenbrock@ukaachen.de … Tenbrock.
This is an open access article distributed under the Creative Commons Attribution License…

Reactive oxygen species (ROS) molecules are implicated in signal transduction pathways
and thereby control a range of biological activities. Immune cells are constantly confronted …

To identify new components that regulate the inflammatory cascade during sepsis, we
characterized the functions of myeloid-related protein-8 (Mrp8, S100A8) and myeloid-related …

Background The study of autoinflammatory diseases has uncovered mechanisms underlying
cytokine dysregulation and inflammation. Methods We analyzed the DNA of an index …

Monocytes and macrophages may either promote or down-regulate inflammatory reactions
depending on their state of activation. The effects of glucocorticoids (GCs), the most widely …

Systemic lupus erythematosus (SLE), an autoimmune disease, develops when immunologic
self‐tolerance fails. Treg cells are a subset of CD4 + T cells that maintain self‐tolerance by …

Background Systemic lupus erythematosus (SLE) is an autoimmune disease with a
prevalence of 36.7/100 000 in Germany and a female/male ratio of 4: 1. The clinical course is …

Background Patients with cystic fibrosis have an increased risk of hyperoxaluria, and of
subsequent nephrocalcinosis and calcium-oxalate urolithiasis. Oxalate homoeostasis is …

Systemic lupus erythematosus (SLE) T cells express high levels of cAMP response element
modulator (CREM) that binds to the IL-2 promoter and represses the transcription of the IL-2 …