Eukaryotic cells have signalling pathways from the endoplasmic reticulum (ER) to cytosol
and nuclei, to avoid excess accumulation of unfolded proteins in the ER. We previously …

To avoid excess accumulation of unfolded proteins in the endoplasmic reticulum (ER),
eukaryotic cells have signaling pathways from the ER to the cytosol or nucleus. These processes …

Background The BRAF-V600E mutation is associated with tumor aggressiveness and poor
prognosis in melanoma patients. Identification of this mutation is clinically important as we …

Myogenic cell cultures derived from muscle biopsies are excellent models for human cell
differentiation. We report the first comprehensive analysis of myogenesis-specific DNA hyper- …

Background Facioscapulohumeral muscular dystrophy (FSHD) is a dominant disease linked
to contraction of an array of tandem 3.3-kb repeats (D4Z4) at 4q35. Within each repeat unit …

Protein lipidation is a common co- or post-translational modification that plays a crucial role
in regulating the localization, interaction and function of cellular proteins. Dysregulation of …

We and others showed that ATP11A and ATP11C, members of the P4-ATPase family,
translocate phosphatidylserine (PS) and phosphatidylethanolamine from the exoplasmic to the …

Background Tight regulation of homeobox genes is essential for vertebrate development. In
a study of genome-wide differential methylation, we recently found that homeobox genes, …

Proteins can be modified by lipids in various ways, for example, by myristoylation, palmitoylation,
farnesylation, and geranylgeranylation—these processes are collectively referred to as …

Background BRAF V600E mutation has been investigated by immunohistochemistry and
has shown high sensitivity and specificity. We aim to investigate the accuracy of …