Although metabolic adaptations have been demonstrated to be essential for tumor cell
proliferation, the metabolic underpinnings of tumor initiation are poorly understood. We found that …

The development and progression of solid tumors is dependent on cancer cell autonomous
drivers and the tumor microenvironment (TME). Cancer-associated fibroblasts (CAFs) in the …

The metazoan-specific POU domain transcription factor family comprises activities underpinning
developmental processes such as embryonic pluripotency and neuronal specification. …

… (K) Quantification of GFP staining. 34 and 31 images from 3 control pre-tamoxifen and 3 …
Carlton for help with ChIPseq, K. Evason for help with independent histological analysis …

High-mobility group box 1 (HMGB1) is a damage-associated molecular pattern (DAMP)
molecule that plays an important role in inflammation and tumorigenesis. Receptor for advanced …

The tumor suppressor BRCA1 regulates the DNA damage response (DDR) and other processes
that remain incompletely defined. Among these, BRCA1 heterodimerizes with BARD1 …

… To discriminate between monovalent and multivalent interactions on quantitative SPR
measurements of K D , the binding affinities of the Fab regions of mAbs were measured using …

In the current issue of Molecular Therapy-Oncolytics, a new study by Yamada and colleagues
1 investigates the effects of combining oncolytic virotherapy with focal adhesion kinase (…

The transcription factor Oct1/Pou2f1 promotes poised gene expression states, mitotic stability,
glycolytic metabolism and other characteristics of stem cell potency. To determine the …

The luminescence and structural properties of layered Y 2 O 3: Eu 3+ phosphors, synthesized
by a simple evaporation method followed by thermal annealing at temperatures up to …