User profiles for K. Welzenbach
Karl WelzenbachNovartis Verified email at novartis.com Cited by 2813 |
Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site
G Weitz-Schmidt, K Welzenbach, V Brinkmann… - Nature medicine, 2001 - nature.com
The β2 integrin leukocyte function antigen-1 (LFA-1) has an important role in the pathophysiology
of inflammatory and autoimmune diseases. Here we report that statin compounds …
of inflammatory and autoimmune diseases. Here we report that statin compounds …
Structural basis for LFA-1 inhibition upon lovastatin binding to the CD11a I-domain
J Kallen, K Welzenbach, P Ramage, D Geyl… - Journal of molecular …, 1999 - Elsevier
The lymphocyte function-associated antigen (LFA-1) belongs to the family of β 2 -integrins
and plays an important role in T-cell activation and leukocyte migration to sites of inflammation…
and plays an important role in T-cell activation and leukocyte migration to sites of inflammation…
Novel immunomodulator FTY720 is phosphorylated in rats and humans to form a single stereoisomer. Identification, chemical proof, and biological characterization of …
…, M Streiff, T Wagner, K Welzenbach… - Journal of medicinal …, 2005 - ACS Publications
In vivo phosphorylation of FTY720 (1) in rats and humans resulted exclusively in the
biologically active (S)-configured enantiomer, which was proven by an ex vivo o-phthaldialdehyde …
biologically active (S)-configured enantiomer, which was proven by an ex vivo o-phthaldialdehyde …
The potent protein kinase C-selective inhibitor AEB071 (sotrastaurin) represents a new class of immunosuppressive agents affecting early T-cell activation
…, K Wagner, J Kovarik, KA Welzenbach… - … of Pharmacology and …, 2009 - ASPET
… In cell-free kinase assays AEB071 inhibited PKC, with K i values in the subnanomolar to low
nanomolar range. Upon T-cell stimulation, AEB071 markedly inhibited in situ PKCθ catalytic …
nanomolar range. Upon T-cell stimulation, AEB071 markedly inhibited in situ PKCθ catalytic …
ADAM17 is the main sheddase for the generation of human triggering receptor expressed in myeloid cells (hTREM2) ectodomain and cleaves TREM2 after Histidine …
…, A Kaykas, DJ Ho, C Ye, K Welzenbach… - Neuroscience …, 2017 - Elsevier
Triggering receptor expressed in myeloid cells (TREM2) is a member of the immunoglobulin
superfamily and is expressed in macrophages, dendritic cells, microglia, and osteoclasts. …
superfamily and is expressed in macrophages, dendritic cells, microglia, and osteoclasts. …
[HTML][HTML] Improved lymphocyte function-associated antigen-1 (LFA-1) inhibition by statin derivatives: molecular basis determined by x-ray analysis and monitoring of …
G Weitz-Schmidt, K Welzenbach, J Dawson… - Journal of Biological …, 2004 - ASBMB
The integrin lymphocyte function-associated antigen-1 (LFA-1) (α L β 2 ; CD11a/CD18)
plays an important role in leukocyte migration and T cell activation. LFA-1 is inhibited by the …
plays an important role in leukocyte migration and T cell activation. LFA-1 is inhibited by the …
CD47 fusion protein targets CD172a+ cells in Crohn's disease and dampens the production of IL-1β and TNF
…, C Heusser, T Huber, K Welzenbach… - Journal of Experimental …, 2013 - rupress.org
In mice, the transfer of CD172a + (SIRP-α) dendritic cells (DCs) elicits T cell–driven colitis,
whereas treatment with CD47-Fc protein, a CD172a-binding agent, confers protection. The …
whereas treatment with CD47-Fc protein, a CD172a-binding agent, confers protection. The …
A rapid method for evaluation of cell number and viability by flow cytometry
M Al-Rubeai, K Welzenbach, DR Lloyd, AN Emery - Cytotechnology, 1997 - Springer
A simple, rapid and reliable method has been developed for assessing the number and
viability of cells, as well as cell size, in suspension culture by the use of flow cytometry. …
viability of cells, as well as cell size, in suspension culture by the use of flow cytometry. …
Pharmacodynamics in the development of new immunosuppressive drugs
…, G Weitz-Schmidt, K Welzenbach - Therapeutic drug …, 2004 - journals.lww.com
Over the past 10-20 years a number of immunosuppressive drugs, such as cyclosporine A,
tacrolimus, sirolimus, or mycophenolate mofetil have been approved for clinical use and have …
tacrolimus, sirolimus, or mycophenolate mofetil have been approved for clinical use and have …
1, 4-Diazepane-2, 5-diones as novel inhibitors of LFA-1
…, U Hommel, G Weckbecker, K Welzenbach… - Bioorganic & medicinal …, 2005 - Elsevier
… Author links open overlay panel Sompong Wattanasin a , Joerg Kallen b , Stewart Myers
a , Qin Guo a , Michael Sabio a , Claus Ehrhardt b , Rainer Albert b , Ulrich Hommel b …
a , Qin Guo a , Michael Sabio a , Claus Ehrhardt b , Rainer Albert b , Ulrich Hommel b …