User profiles for K.E. Hopperton

kathryn hopperton

Hospital for Sick Children, University of Toronto
Verified email at mail.utoronto.ca
Cited by 1883

[HTML][HTML] Markers of microglia in post-mortem brain samples from patients with Alzheimer's disease: a systematic review

KE Hopperton, D Mohammad, MO Trépanier… - Molecular …, 2018 - nature.com
Neuroinflammation is proposed as one of the mechanisms by which Alzheimer’s disease
pathology, including amyloid-β plaques, leads to neuronal death and dysfunction. Increases in …

[HTML][HTML] Postmortem evidence of cerebral inflammation in schizophrenia: a systematic review

MO Trépanier, KE Hopperton, R Mizrahi… - Molecular …, 2016 - nature.com
Schizophrenia is a psychiatric disorder which has a lifetime prevalence of~ 1%. Multiple
candidate mechanisms have been proposed in the pathogenesis of schizophrenia. One such …

[HTML][HTML] Essential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the mouse developing brain

…, C Lacabanne, A Thomazeau, KE Hopperton… - Nature …, 2020 - nature.com
Omega-3 fatty acids (n-3 PUFAs) are essential for the functional maturation of the brain.
Westernization of dietary habits in both developed and developing countries is accompanied by …

[HTML][HTML] Plasma non-esterified docosahexaenoic acid is the major pool supplying the brain

CT Chen, AP Kitson, KE Hopperton… - Scientific reports, 2015 - nature.com
k * and J in from the continuous iv infusion are not significantly different from the predictive k
* … Statistical comparisons of gavage k *UE /J in and iv k *UE /J in as well as icv predictive k *…

N-3 polyunsaturated fatty acids in animal models with neuroinflammation: an update

MO Trépanier, KE Hopperton, SK Orr… - European journal of …, 2016 - Elsevier
Neuroinflammation is a characteristic of a multitude of neurological and psychiatric disorders.
Modulating inflammatory pathways offers a potential therapeutic target in these disorders. …

[HTML][HTML] Brain omega-3 polyunsaturated fatty acids modulate microglia cell number and morphology in response to intracerebroventricular amyloid-β 1-40 in mice

KE Hopperton, MO Trépanier, V Giuliano… - Journal of …, 2016 - Springer
Background Neuroinflammation is a proposed mechanism by which Alzheimer’s disease (AD)
pathology potentiates neuronal death and cognitive decline. Consumption of omega-3 …

Fatty acid synthase plays a role in cancer metabolism beyond providing fatty acids for phospholipid synthesis or sustaining elevations in glycolytic activity

KE Hopperton, RE Duncan, RP Bazinet… - Experimental cell …, 2014 - Elsevier
Fatty acid synthase is over-expressed in many cancers and its activity is required for cancer
cell survival, but the role of endogenously synthesized fatty acids in cancer is unknown. It …

Palmitate-induced inflammatory pathways in human adipose microvascular endothelial cells promote monocyte adhesion and impair insulin transcytosis

…, C Wang, KL Chan, KE Hopperton… - American Journal …, 2015 - journals.physiology.org
Obesity is associated with inflammation and immune cell recruitment to adipose tissue,
muscle and intima of atherosclerotic blood vessels. Obesity and hyperlipidemia are also …

[HTML][HTML] Hepatocyte-specific deletion of Janus kinase 2 (JAK2) protects against diet-induced steatohepatitis and glucose intolerance

…, SA Schroer, EP Cai, CT Luk, KE Hopperton… - Journal of Biological …, 2012 - ASBMB
Non-alcoholic fatty liver disease (NAFLD) is becoming the leading cause of chronic liver
disease and is now considered to be the hepatic manifestation of the metabolic syndrome. …

Oxylipin concentration, but not fatty acid composition, is altered in human donor milk pasteurised using both thermal and non-thermal techniques

MA Pitino, SM Alashmali, KE Hopperton… - British journal of …, 2019 - cambridge.org
Human donor milk (DM) is Holder pasteurised (62·5C, 30 min) to ensure its microbiological
safety for infant consumption. In low-resource settings, flash heating is used to pasteurise milk…