User profiles for K.N. Manolopoulos

Konstantinos Manolopoulos

University of Birmingham
Verified email at bham.ac.uk
Cited by 3175

Gluteofemoral body fat as a determinant of metabolic health

KN Manolopoulos, F Karpe, KN Frayn - International journal of obesity, 2010 - nature.com
Body fat distribution is an important metabolic and cardiovascular risk factor, because the
proportion of abdominal to gluteofemoral body fat correlates with obesity-associated diseases …

Linking Alzheimer's disease to insulin resistance: the FoxO response to oxidative stress

KN Manolopoulos, LO Klotz, P Korsten… - Molecular …, 2010 - nature.com
Oxidative stress is an important determinant not only in the pathogenesis of Alzheimer's
disease (AD), but also in insulin resistance (InsRes) and diabetic complications. Forkhead box …

Oxygenation of adipose tissue: A human perspective

…, RLJ van Meijel, KN Manolopoulos… - Acta …, 2020 - Wiley Online Library
Obesity is a complex disorder of excessive adiposity, and is associated with adverse health
effects such as cardiometabolic complications, which are to a large extent attributable to …

[PDF][PDF] Nicotinamide riboside augments the aged human skeletal muscle NAD+ metabolome and induces transcriptomic and anti-inflammatory signatures

…, P Nightingale, GA Wallis, KN Manolopoulos… - Cell reports, 2019 - cell.com
Nicotinamide adenine dinucleotide (NAD + ) is modulated by conditions of metabolic stress
and has been reported to decline with aging in preclinical models, but human data are …

Distinct developmental profile of lower-body adipose tissue defines resistance against obesity-associated metabolic complications

…, KN Manolopoulos, SE McQuaid, P Valet, KN Frayn… - Diabetes, 2014 - Am Diabetes Assoc
Upper- and lower-body fat depots exhibit opposing associations with obesity-related metabolic
disease. We defined the relationship between DEXA-quantified fat depots and diabetes/…

[HTML][HTML] Polycystic ovary syndrome, androgen excess, and the risk of nonalcoholic fatty liver disease in women: a longitudinal study based on a United Kingdom …

B Kumarendran, MW O'Reilly, KN Manolopoulos… - PLoS …, 2018 - journals.plos.org
Background Androgen excess is a defining feature of polycystic ovary syndrome (PCOS),
which affects 10% of women and represents a lifelong metabolic disorder, with increased risk …

Cardiometabolic disease burden and steroid excretion in benign adrenal tumors: a cross-sectional multicenter study

…, WF Young Jr, KN Manolopoulos… - Annals of internal …, 2022 - acpjournals.org
Background: Benign adrenal tumors are commonly discovered on cross-sectional imaging.
Mild autonomous cortisol secretion (MACS) is regularly diagnosed, but its effect on …

AKR1C3-mediated adipose androgen generation drives lipotoxicity in women with polycystic ovary syndrome

…, M Walsh, AE Taylor, KN Manolopoulos… - The Journal of …, 2017 - academic.oup.com
Context Polycystic ovary syndrome (PCOS) is a prevalent metabolic disorder occurring in
up to 10% of women of reproductive age. PCOS is associated with insulin resistance and …

Mobilising vitamin D from adipose tissue: The potential impact of exercise

…, JA Betts, M Hewison, KN Manolopoulos… - Nutrition …, 2019 - Wiley Online Library
Vitamin D is lipophilic and accumulates substantially in adipose tissue. Even without
supplementation, the amount of vitamin D in the adipose of a typical adult is equivalent to several …

[HTML][HTML] Distinct inflammatory signatures of upper and lower body adipose tissue and adipocytes in women with normal weight or obesity

…, R Dineen, EE Blaak, KN Manolopoulos… - Frontiers in …, 2023 - frontiersin.org
Introduction Upper and lower body fat accumulation poses an opposing obesity-related
cardiometabolic disease risk. Depot-differences in subcutaneous adipose tissue (SAT) function …