The human cardiovascular system is a complex arrangement of specialized structures with
distinct functions. The molecular landscape, including the genome, transcriptome and …

Mϕ proliferation, differentiation, and survival are controlled by signals from the Mϕ CSF
receptor (CSF1R). Mono-allelic gain-of-function mutations in CSF1R in humans are associated …

The issue of inherited disorders and poor health in pedigree dogs has been widely
discussed in recent years. With the advent of genome-wide sequencing technologies and the …

Microglia have critical roles in neural development, homeostasis and neuroinflammation
and are increasingly implicated in age-related neurological dysfunction. Neurodegeneration …

Although it is generally accepted that cellular differentiation requires changes to transcriptional
networks, dynamic regulation of promoters and enhancers at specific sets of genes has …

MicroRNAs (miRNAs) are short non-coding RNAs with key roles in cellular regulation. As part
of the fifth edition of the Functional Annotation of Mammalian Genome (FANTOM5) project, …

… Csf1r ΔFIRE/ΔFIRE mice have fewer total CD45 + cells and the F4/80 hi CD11b lo resident
kidney macrophages (KM) 38 are undetectable (Fig. 5b). In both control and mutant, a subset …

In the FANTOM5 project, transcription initiation events across the human and mouse genomes
were mapped at a single base-pair resolution and their frequencies were monitored by …

Sequencing of candidate genes for obesity in Labrador retriever dogs identified a 14 bp
deletion in pro-opiomelanocortin (POMC) with an allele frequency of 12%. The deletion disrupts …

Background This work describes the first genome-wide analysis of the transcriptional landscape
of the pig. A new porcine Affymetrix expression array was designed in order to provide …