The protein kinase Akt is one of the primary effectors of growth factor signaling in the cell.
Akt responds specifically to the lipid second messengers phosphatidylinositol-3,4,5-…

3-phosphoinositide-dependent kinase 1 (PDK1) is an essential serine/threonine protein
kinase, which plays a crucial role in cell growth and proliferation. It is often referred to as a ‘…

Lipid droplets (LDs) are dynamic organelles that contain an oil core mainly composed of
triglycerides (TAG) that is surrounded by a phospholipid monolayer and LD-associated proteins …

The class IB phosphoinositide 3-kinase (PI3K), PI3Kγ, is a master regulator of immune cell
function and a promising drug target for both cancer and inflammatory diseases. Critical to …

Class I Phosphoinositide 3-kinases (PI3Ks) are master regulators of cellular functions, with
the class IB PI3K catalytic subunit (p110g) playing key roles in immune signalling. p110g is a …

Phospholipid synthesis and fat storage as triglycerides are regulated by lipin phosphatidic
acid phosphatases (PAPs), whose enzymatic PAP function requires association with cellular …

The TRAnsport Protein Particle (TRAPP) complexes act as Guanine nucleotide exchange
factors (GEFs) for Rab GTPases, which are master regulators of membrane trafficking in …

Class IB phosphoinositide 3-kinase (PI3Kγ) is activated in immune cells and can form two
distinct complexes (p110γ-p84 and p110γ-p101), which are differentially activated by G protein…

Transport Protein Particle complexes (TRAPP) are evolutionarily conserved regulators of
membrane trafficking, with this mediated by their guanine nucleotide exchange factor (GEF) …

There is considerable interest in developing antibodies as modulators of signaling pathways.
One of the most important signaling pathways in higher eukaryotes is the phosphoinositide …