Background The success of the CRISPR/Cas9 genome editing technique depends on the
choice of the guide RNA sequence, which is facilitated by various websites. Despite the …

We describe two new transgenic mouse lines for studying pathological changes of Tau protein
related to Alzheimer's disease. They are based on the regulatable expression of the four-…

We describe a transgenic mouse line, Pax8-rtTA, which, under control of the mouse Pax8
promoter, directs high levels of expression of the reverse tetracycline–dependent transactivator …

The strategy of modulating gene activities in vivo via CRE/loxP recombination would greatly
profit from subjecting the recombination event to an independent and stringent temporal …

Neurofibrillary lesions are characteristic for a group of human diseases, named tauopathies,
which are characterized by prominent intracellular accumulations of abnormal filaments …

Hereditary angioedema type III (HAEIII) is a rare inherited swelling disorder that is associated
with point mutations in the gene encoding the plasma protease factor XII (FXII). Here, we …

Based on the tetracycline-regulated gene expression system, a double-transgenic mouse
model for liver fibrosis was established in which the expression of transforming growth factor …

Conversion of soluble α-synuclein into insoluble and fibrillar inclusions is a hallmark of
Parkinson’s disease and other synucleinopathies. Accumulating evidence points towards a …

Loss of control over drinking is a key deficit in alcoholism causally associated with malfunction
of the medial prefrontal cortex (mPFC), but underlying molecular and cellular mechanisms …

Alcohol-dependent patients commonly show impairments in executive functions that facilitate
craving and can lead to relapse. However, the molecular mechanisms leading to executive …