The genomes of malaria parasites contain many genes of unknown function. To assist drug
development through the identification of essential genes and pathways, we have measured …

hrp genes, basic pathogenicity genes of the pepper and tomato pathogen Xanthomonas
campestris pv. vesicatoria, are regulated dependent on environmental conditions. We isolated …

We isolated a novel, NTG induced hrp mutant (E2-12) of X. campestris pv. vesicatoria 85E
that failed to cause disease in a susceptible plant and did not induce the HR in resistant plants…

The malaria parasite suffers severe population losses as it passes through its mosquito
vector. Contributing factors are the essential but highly constrained developmental transitions …

The hrp cluster of the pepper and tomato pathogen Xanthomonas campestris pv. vesicatoria
is required for both pathogenicity on susceptible host plants and induction of the …

Studies of essential pathogenicity determinants in Gram-negative bacteria have revealed the
conservation of type III protein secretion systems that allow delivery of virulence factors into …

Hereditary xerocytosis is thought to be a rare genetic condition characterized by red blood
cell (RBC) dehydration with mild hemolysis. RBC dehydration is linked to reduced …

hrpG is a key regulatory gene for transcriptional activation of pathogenicity genes (hrp)
ofXanthomonas campestris pv. vesicatoria. We identified three mutations in hrpG which render …

During asexual development within erythrocytes, malaria parasites synthesize considerable
amounts of membrane. This activity provides an attractive target for chemotherapy because …

Phosphoinositides are important regulators of diverse cellular functions, and phosphatidylinositol
3-monophosphate (PI3P) is a key element in vesicular trafficking processes. During its …