The recent discovery of mutations in metabolic enzymes has rekindled interest in harnessing
the altered metabolism of cancer cells for cancer therapy. One potential drug target is …

Cancer cells engage in a metabolic program to enhance biosynthesis and support cell
proliferation. The regulatory properties of pyruvate kinase M2 (PKM2) influence altered glucose …

Recurrent mutations in the spliceosome are observed in several human cancers, but their
functional and therapeutic significance remains elusive. SF3B1, the most frequently mutated …

Homozygous deletions of p16/CDKN2A are prevalent in cancer, and these mutations commonly
involve co-deletion of adjacent genes, including methylthioadenosine phosphorylase (…

We have identified a critical role for amplified FGFR2 in gastric cancer cell proliferation and
survival. In a panel of gastric cancer cell lines, fibroblast growth factor receptor 2 (FGFR2) …

Orexins (orexin-A and -B) are recently identified neuropeptides, which are thought to be
implicated in the regulation of feeding behavior. We used a NPY-Y1 receptor specific antagonist, …

Optimization of a series of R132H IDH1 inhibitors from a high throughput screen led to the first
potent molecules that show robust tumor 2-HG inhibition in a xenograft model. Compound …

Chronic inflammation has been postulated to play an important role in the pathogenesis of
insulin resistance. Inducible nitric oxide synthase (iNOS) has been implicated in many human …

Orexin/hypocretins are recently identified neuropeptides which regulate feeding behaviour.
We found orexins increased water intake when administrated intracerebroventricularly to rats…

Proliferating tumor cells use aerobic glycolysis to support their high metabolic demands.
Paradoxically, increased glycolysis is often accompanied by expression of the lower activity …