Search for early pancreatic cancer blood biomarkers in five European prospective population biobanks using metabolomics

…, K Hveem, T Haller, N Tonisson, K Mikkel… - …, 2019 - academic.oup.com
Most patients with pancreatic cancer present with advanced disease and die within the first
year after diagnosis. Predictive biomarkers that signal the presence of pancreatic cancer in …

[HTML][HTML] Mutation Frequency and Spectrum of Mutations Vary at Different Chromosomal Positions of Pseudomonas putida

…, T Ilmjärv, K Tavita, K Ukkivi, A Teppo, K Mikkel… - PLoS …, 2012 - journals.plos.org
It is still an open question whether mutation rate can vary across the bacterial chromosome.
In this study, the occurrence of mutations within the same mutational target sequences at …

NHEJ enzymes LigD and Ku participate in stationary-phase mutagenesis in Pseudomonas putida

Ü Paris, K Mikkel, K Tavita, S Saumaa, R Teras… - DNA repair, 2015 - Elsevier
Under growth-restricting conditions bacterial populations can rapidly evolve by a process
known as stationary-phase mutagenesis. Bacterial nonhomologous end-joining (NHEJ) …

Eesti haruldaste haiguste arengukava koos tegevusplaaniga aastateks 2015–2017

V Tillmann, T Talvik, R Teek, K Joost, I Talvik, S Mikkel… - Eesti Arst, 2014 - ojs.utlib.ee
Euroopa Komisjoni 2008. aasta teatises (1) ja 2009. aasta soovitustes (2) on tehtud ettepanek
igal Euroopa Liidu liikmesriigil välja töötada oma haruldaste haiguste ehk harvikhaiguste …

Homologous recombination is facilitated in starving populations of Pseudomonas putida by phenol stress and affected by chromosomal location of the recombination …

K Tavita, K Mikkel, M Tark-Dame, H Jerabek… - Mutation Research …, 2012 - Elsevier
Homologous recombination (HR) has a major impact in bacterial evolution. Most of the
knowledge about the mechanisms and control of HR in bacteria has been obtained in fast …

[HTML][HTML] Linking a population biobank with national health registries—the Estonian experience

L Leitsalu, H Alavere, ML Tammesoo, E Leego… - Journal of personalized …, 2015 - mdpi.com
… The authors would also like to express their gratitude to all the scientists and technical
staff of the EGCUT, in particular Kairit Mikkel and Toomas Haller. …

Occupational irritants and asthma: an Estonian cross-sectional study of 34 000 adults

O Dumas, E Laurent, J Bousquet… - European …, 2014 - Eur Respiratory Soc
Occupational exposures make important contributions to asthma morbidity. The role of low/moderate
level irritant exposures remains unclear. We aimed to determine which …

Leveraging biobank-scale rare and common variant analyses to identify ASPHD1 as the main driver of reproductive traits in the 16p11.2 locus

K Männik, T Arbogast, M Lepamets, K Lepik, A Pellaz… - BioRxiv, 2019 - biorxiv.org
… responsibilities especially Lili Milani, Viljo Soo, Kairit Mikkel and Mari-Liis Tammesoo. We
thank 16p11.2 Pan-European enrollees and their families for their contribution to this study. …

Linking a Population Biobank with National Health Registries--The Estonian Experience.

H Alavere, ML Tammesoo, L Leitsalu… - Journal of …, 2015 - search.ebscohost.com
… The authors would also like to express their gratitude to all the scientists and technical
staff of the EGCUT, in particular Kairit Mikkel and Toomas Haller. …

Copy number variations and cognitive phenotypes in unselected populations

K Männik, R Mägi, A Macé, B Cole, AL Guyatt… - Jama, 2015 - jamanetwork.com
Importance The association of copy number variations (CNVs), differing numbers of copies
of genetic sequence at locations in the genome, with phenotypes such as intellectual …