The cytokine interleukin (IL)-1β is a key mediator of antimicrobial immunity as well as
autoimmune inflammation. Production of IL-1β requires transcription by innate immune receptor …

Cognitive impairment is a frequent manifestation of neuropsychiatric systemic lupus
erythematosus, present in up to 80% of patients and leading to a diminished quality of life. In the …

Neuropsychiatric lupus (NPSLE) is a debilitating manifestation of SLE which occurs in a majority
of SLE patients and has a variety of clinical manifestations. In the central nervous system…

Antigen-activated lymphocytes undergo extraordinarily rapid cell division in the course of
immune responses. We hypothesized that this unique aspect of lymphocyte biology leads to …

A wide range of patients with systemic lupus erythematosus (SLE) suffer from cognitive
dysfunction (CD) which severely impacts their quality of life. However, CD remains …

… Both Drs Kaitlin R Carroll and Jonathan D Katz co-wrote and edited this article, much of
which derived from Dr Carroll’s dissertation work under the supervision of Dr. Katz. The figures …

Preserving endogenous insulin production is clinically advantageous and remains a vital
unmet challenge in the treatment and reversal of type 1 diabetes. Although broad …

Cognitive impairment is a frequent manifestation of neuropsychiatric systemic lupus erythematosus
(NPSLE), present in up to 80% of patients and leading to a diminished quality of life. …

While IL-1β is critical for anti-microbial host defense, it is also a key mediator of autoimmune
inflammation. Inflammasome activation following pathogenic insults is known to result in IL-…

Importance Multisystem inflammatory syndrome in children (MIS-C) is associated with recent
or current SARS-CoV-2 infection. Information on MIS-C incidence is limited. Objective To …