[HTML][HTML] A comprehensive single-cell breast tumor atlas defines epithelial and immune heterogeneity and interactions predicting anti-PD-1 therapy response

L Xu, K Saunders, SP Huang, H Knutsdottir… - Cell Reports …, 2024 - cell.com
We present an integrated single-cell RNA sequencing atlas of the primary breast tumor
microenvironment (TME) containing 236,363 cells from 119 biopsy samples across eight datasets…

A comprehensive single-cell breast tumor atlas defines cancer epithelial and immune cell heterogeneity and interactions predicting anti-PD-1 therapy response

L Xu, K Saunders, H Knutsdottir, K Chen, J Maués… - bioRxiv, 2022 - biorxiv.org
We present an integrated single-cell RNA-seq resource of the breast tumor microenvironment
consisting of 236,363 cells from 119 biopsy samples across 8 publicly available datasets. …

Abstract A041: Treating liver metastases by reversing cell competition between metastatic cancer cells and hepatocytes

…, S Mohta, CA Smith, V Repaka, L Xu, K Saunders… - Cancer Research, 2024 - AACR
Background Although breast cancer liver metastases (BCLM) are common events, with 40-50%
of patients with metastatic breast cancer developing liver metastases, their development …

993 InteractPrint predicts clinically meaningful interactions between cancer epithelial cells and immune cells: lessons from a single-cell breast cancer atlas

L Xu, K Saunders, H Knutsdottir, K Chen, J Maués… - 2022 - jitc.bmj.com
Background While immunotherapy has revolutionized the treatment of many solid tumors,
the efficacy of immunotherapy regimens is comparatively lower in breast cancer. …

Abstract GS5-06: InteractPrint predicts clinically meaningful interactions between cancer epithelial cells and immune cells: Lessons from a single-cell breast cancer …

L Xu, K Saunders, H Knutsdottir, K Chen, J Maues… - Cancer Research, 2023 - AACR
BACKGROUND: While immunotherapy has revolutionized the treatment of many solid
tumors, the efficacy of immunotherapy regimens is comparatively lower in breast cancer. …

Organoid generation from mouse mammary tumors captures the genetic heterogeneity of clinically relevant copy number alterations

…, CA Smith, K Martinez-Algarin, K Saunders… - bioRxiv, 2023 - biorxiv.org
Breast cancer metastases exhibit many different genetic alterations, including copy number
amplifications. Using publicly available datasets, we identify copy number amplifications in …

Digital Droplet PCR analysis of organoids generated from mouse mammary tumors demonstrates proof-of-concept capture of tumor heterogeneity

KE Lake, MM Colonnetta, CA Smith, K Saunders… - Frontiers in Cell and … - frontiersin.org
Breast cancer metastases exhibit many different genetic alterations, including copy number
amplifications (CNA). CNA are genetic alterations that are increasingly becoming relevant to …

[HTML][HTML] Associations between use of self-regulatory strategies and daily eating patterns: An experience sampling study in college-aged women

RB Lopez, D Cosme, KM Werner, B Saunders… - Motivation and …, 2021 - Springer
Previous theorizing suggests there are multiple means by which people regulate their
emotions and impulses, but that these strategies vary in the degree to which they support goal …

Safety, tolerability, and immunogenicity of two Zika virus DNA vaccine candidates in healthy adults: randomised, open-label, phase 1 clinical trials

…, RS Rothwell, N Berkowitz, F Mendoza, JG Saunders… - The Lancet, 2018 - thelancet.com
Background The Zika virus epidemic and associated congenital infections have prompted
rapid vaccine development. We assessed two new DNA vaccines expressing premembrane …

A multisite preregistered paradigmatic test of the ego-depletion effect

…, IF Russ, M Salvati, B Saunders… - Psychological …, 2021 - journals.sagepub.com
We conducted a preregistered multilaboratory project (k = 36; N = 3,531) to assess the size
and robustness of ego-depletion effects using a novel replication method, termed the …