The genome of male germ cells is actively transcribed during spermatogenesis to produce
phase-specific protein-coding mRNAs and a considerable amount of different noncoding …

The free-living flatworm, Macrostomum lignano has an impressive regenerative capacity.
Following injury, it can regenerate almost an entirely new organism because of the presence of …

Background Gout is the most common cause of inflammatory arthritis worldwide, particularly
in Pacific regions. We aimed to establish the prevalence of gout and hyperuricaemia in …

Background Low pass sequencing has been proposed as a cost-effective alternative to
genotyping arrays to identify genetic variants that influence multifactorial traits in humans. For …

Piwi proteins and their associated small RNAs are essential for fertility in animals. In part,
this is due to their roles in guarding germ cell genomes against the activity of mobile genetic …

PIWI proteins and their associated piRNAs protect germ cells from the activity of mobile
genetic elements. Two classes of piRNAs—primary and secondary—are defined by their …

Despite increasing calls for benefit sharing to promote greater equity in human genomic
research, established precedents across the private and public spheres are lacking. Moreover, …

PIWI proteins and piRNA pathways are essential for transposon silencing and some aspects
of gene regulation during animal germline development. In contrast to most animal species, …

Background Historically, geneticists have relied on genotyping arrays and imputation to
study human genetic variation. However, an underrepresentation of diverse populations has …

This year's 40th season of Keystone symposia meetings was held in Banff, Alberta, Canada,
on February 11–16 and sponsored by Astellas Pharma and Regulus Therapeutics. The …